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http://www.ncbi.nlm.nih.gov/pubmed/17134501
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http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
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PMID: 12905466
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http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
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<celldesigner:gene id="gn29" name="TNFAIP3" type="GENE"/>
<celldesigner:gene id="gn30" name="SOD2" type="GENE"/>
<celldesigner:gene id="gn31" name="PDE4B" type="GENE"/>
<celldesigner:gene id="gn32" name="ADM" type="GENE"/>
<celldesigner:gene id="gn33" name="JUNB" type="GENE"/>
<celldesigner:gene id="gn34" name="NAMPT" type="GENE"/>
<celldesigner:gene id="gn35" name="MMP3" type="GENE"/>
<celldesigner:gene id="gn36" name="MMP1" type="GENE"/>
<celldesigner:gene id="gn37" name="MIR155" type="GENE"/>
<celldesigner:gene id="gn40" name="BCL2A1" type="GENE"/>
<celldesigner:gene id="gn41" name="MIR346" type="GENE"/>
<celldesigner:gene id="gn42" name="unknown TF" type="GENE"/>
<celldesigner:gene id="gn43" name="BTK" type="GENE"/>
<celldesigner:gene id="gn44" name="MIR146A" type="GENE"/>
<celldesigner:gene id="gn45" name="TRAF6" type="GENE"/>
<celldesigner:gene id="gn46" name="IRAK1" type="GENE"/>
<celldesigner:gene id="gn66" name="BCL2L11" type="GENE"/>
<celldesigner:gene id="gn67" name="FASLG" type="GENE"/>
<celldesigner:gene id="gn68" name="CDKN1B" type="GENE"/>
<celldesigner:gene id="gn69" name="YWHAQ" type="GENE"/>
<celldesigner:gene id="gn70" name="BAX" type="GENE"/>
<celldesigner:gene id="gn71" name="PMAIP1" type="GENE"/>
<celldesigner:gene id="gn72" name="TNFRSF10A" type="GENE"/>
<celldesigner:gene id="gn73" name="TNFRSF10B" type="GENE"/>
<celldesigner:gene id="gn75" name="SERPINE1" type="GENE"/>
<celldesigner:gene id="gn76" name="PERP" type="GENE"/>
<celldesigner:gene id="gn77" name="THBS1" type="GENE"/>
<celldesigner:gene id="gn78" name="MDM2" type="GENE"/>
<celldesigner:gene id="gn79" name="CSF2" type="GENE"/>
<celldesigner:gene id="gn18" name="IL8" type="GENE"/>
<celldesigner:gene id="gn81" name="IL18" type="GENE"/>
<celldesigner:gene id="gn82" name="VEGFA" type="GENE"/>
<celldesigner:gene id="gn84" name="JUP" type="GENE"/>
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<celldesigner:RNA id="rn2" name="CCL4" type="RNA"/>
<celldesigner:RNA id="rn4" name="ICAM1" type="RNA"/>
<celldesigner:RNA id="rn6" name="IL6" type="RNA"/>
<celldesigner:RNA id="rn7" name="NFKBIA" type="RNA"/>
<celldesigner:RNA id="rn8" name="CROP" type="RNA"/>
<celldesigner:RNA id="rn10" name="IL1RN" type="RNA"/>
<celldesigner:RNA id="rn12" name="PTGS2" type="RNA"/>
<celldesigner:RNA id="rn13" name="ZFP36" type="RNA"/>
<celldesigner:RNA id="rn14" name="TNF" type="RNA"/>
<celldesigner:RNA id="rn15" name="TRAF1" type="RNA"/>
<celldesigner:RNA id="rn16" name="PPP1R15A" type="RNA"/>
<celldesigner:RNA id="rn17" name="DUSP2" type="RNA"/>
<celldesigner:RNA id="rn18" name="TNFAIP3" type="RNA"/>
<celldesigner:RNA id="rn19" name="SOD2" type="RNA"/>
<celldesigner:RNA id="rn3" name="IL1B" type="RNA"/>
<celldesigner:RNA id="rn20" name="PDE4B" type="RNA"/>
<celldesigner:RNA id="rn21" name="ADM" type="RNA"/>
<celldesigner:RNA id="rn22" name="JUNB" type="RNA"/>
<celldesigner:RNA id="rn23" name="NAMPT" type="RNA"/>
<celldesigner:RNA id="rn24" name="MMP3" type="RNA"/>
<celldesigner:RNA id="rn25" name="MMP1" type="RNA"/>
<celldesigner:RNA id="rn27" name="BCL2A1" type="RNA"/>
<celldesigner:RNA id="rn28" name="MIR346" type="RNA"/>
<celldesigner:RNA id="rn29" name="unknown TF" type="RNA"/>
<celldesigner:RNA id="rn30" name="BTK" type="RNA"/>
<celldesigner:RNA id="rn31" name="MIR146A" type="RNA"/>
<celldesigner:RNA id="rn32" name="TRAF6" type="RNA"/>
<celldesigner:RNA id="rn33" name="IRAK1" type="RNA"/>
<celldesigner:RNA id="rn34" name="BCL2L11" type="RNA"/>
<celldesigner:RNA id="rn35" name="FASLG" type="RNA"/>
<celldesigner:RNA id="rn36" name="CDKN1B" type="RNA"/>
<celldesigner:RNA id="rn37" name="YWHAQ" type="RNA"/>
<celldesigner:RNA id="rn38" name="BAX" type="RNA"/>
<celldesigner:RNA id="rn39" name="PMAIP1" type="RNA"/>
<celldesigner:RNA id="rn40" name="TNFRSF10A" type="RNA"/>
<celldesigner:RNA id="rn41" name="TNFRSF10B" type="RNA"/>
<celldesigner:RNA id="rn42" name="SERPINE1" type="RNA"/>
<celldesigner:RNA id="rn43" name="PERP" type="RNA"/>
<celldesigner:RNA id="rn44" name="THBS1" type="RNA"/>
<celldesigner:RNA id="rn45" name="MDM2" type="RNA"/>
<celldesigner:RNA id="rn46" name="CSF2" type="RNA"/>
<celldesigner:RNA id="rn11" name="IL8" type="RNA"/>
<celldesigner:RNA id="rn49" name="IL18" type="RNA"/>
<celldesigner:RNA id="rn50" name="VEGFA" type="RNA"/>
<celldesigner:RNA id="rn51" name="IFNB1" type="RNA"/>
<celldesigner:RNA id="rn52" name="CCND1" type="RNA"/>
<celldesigner:RNA id="rn53" name="JUP" type="RNA"/>
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</celldesigner:listOfAntisenseRNAs>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
</celldesigner:extension>
</annotation>
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<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00909" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00910" kind="litre"/>
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</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
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<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
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</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00913" kind="second"/>
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</unitDefinition>
</listOfUnitDefinitions>
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<compartment metaid="c1" id="c1" name="Cytosol" size="1" units="volume" outside="c2">
<annotation>
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<celldesigner:name>Cytosol</celldesigner:name>
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</annotation>
</compartment>
<compartment metaid="c2" id="c2" name="Membrane" size="1" units="volume" outside="default">
<annotation>
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<celldesigner:name>Membrane</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c6" id="c6" name="nucleus" size="1" units="volume" outside="c2">
<annotation>
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<celldesigner:name>nucleus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c7" id="c7" name="Mitochondrion" size="1" units="volume" outside="c2">
<annotation>
<celldesigner:extension>
<celldesigner:name>Mitochondrion</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c8" id="c8" name="endoplasmic reticulum" size="1" units="volume" outside="c2">
<annotation>
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<celldesigner:name>endoplasmic reticulum</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c9" id="c9" name="Golgi apparatus" size="1" units="volume" outside="c2">
<annotation>
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<celldesigner:name>Golgi apparatus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c10" id="c10" name="c10" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>c10</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
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<listOfSpecies>
<species metaid="s858" id="s858" name="ABL1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
</species>
<species metaid="s1097" id="s1097" name="ACTB" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
</species>
<species metaid="s1173" id="s1173" name="ACTC1" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:proteinReference>pr590</celldesigner:proteinReference>
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</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn21</celldesigner:rnaReference>
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<celldesigner:catalyzed reaction="re67"/>
<celldesigner:catalyzed reaction="re73"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s226" id="s226" name="ADM" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn32</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s746" id="s746" name="ADRBK2" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr401</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
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<celldesigner:catalyzed reaction="re187"/>
<celldesigner:catalyzed reaction="re339"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1241" id="s1241" name="AKT2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr139</celldesigner:proteinReference>
<celldesigner:state>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
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<celldesigner:catalyzed reaction="re94"/>
<celldesigner:catalyzed reaction="re160"/>
<celldesigner:catalyzed reaction="re162"/>
<celldesigner:catalyzed reaction="re164"/>
<celldesigner:catalyzed reaction="re195"/>
<celldesigner:catalyzed reaction="re216"/>
<celldesigner:catalyzed reaction="re218"/>
<celldesigner:catalyzed reaction="re228"/>
<celldesigner:catalyzed reaction="re299"/>
<celldesigner:catalyzed reaction="re301"/>
<celldesigner:catalyzed reaction="re320"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1240" id="s1240" name="AKT2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr139</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s748" id="s748" name="ARHGDIB" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/15479887
PMID: 15479887
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr402</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re188"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s749" id="s749" name="ARHGEF1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr403</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re188"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s474" id="s474" name="ARHGEF2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr173</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s401" id="s401" name="Actin Based Motility" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Actin Based Motility</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1137" id="s1137" name="Apoptosis" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Apoptosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1002" id="s1002" name="Apoptosis" compartment="c6" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Apoptosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1148" id="s1148" name="BAD" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr580</celldesigner:proteinReference>
<celldesigner:state>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1143" id="s1143" name="BAD" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr580</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1144" id="s1144" name="BAD/S100A10" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>BAD/S100A10</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re189"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s713" id="s713" name="BAX" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn38</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s712" id="s712" name="BAX" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn70</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s756" id="s756" name="BCL2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr406</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s753" id="s753" name="BCL2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr406</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s333" id="s333" name="BCL2A1" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn27</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s332" id="s332" name="BCL2A1" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn40</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s701" id="s701" name="BCL2L11" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn34</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s700" id="s700" name="BCL2L11" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn66</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s350" id="s350" name="BTK" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn30</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re333"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s348" id="s348" name="BTK" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
 PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn43</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s825" id="s825" name="CALM1,3" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr453</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re212"/>
<celldesigner:catalyzed reaction="re213"/>
<celldesigner:catalyzed reaction="re215"/>
<celldesigner:catalyzed reaction="re238"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s822" id="s822" name="CALM1,3" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr453</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s131" id="s131" name="CASP8" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr42</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s389" id="s389" name="CASP8AP2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19191904
PMID: 19191904
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr141</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re34"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s832" id="s832" name="CASP9" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr459</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s831" id="s831" name="CASP9" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr459</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s833" id="s833" name="CAV1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr460</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re280"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s188" id="s188" name="CCL4" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 18454843
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn2</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re56"/>
<celldesigner:catalyzed reaction="re68"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s187" id="s187" name="CCL4" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn16</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s254" id="s254" name="CCNA2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr74</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1183" id="s1183" name="CCNB1/CDC2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>CCNB1/CDC2</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re245"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1182" id="s1182" name="CCNB1/CDC2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>CCNB1/CDC2</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s184" id="s184" name="CCND1" compartment="c10" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn14</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s255" id="s255" name="CCND2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr75</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1184" id="s1184" name="CCNH/CDK7" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>CCNH/CDK7</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re258"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1051" id="s1051" name="CD14" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr559</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s770" id="s770" name="CD19" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr417</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re118"/>
<celldesigner:catalyzed reaction="re191"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s977" id="s977" name="CD28" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr538</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re118"/>
<celldesigner:catalyzed reaction="re208"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1022" id="s1022" name="CD3E" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr557</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s849" id="s849" name="CDC25B,C" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
CDC25B: http://www.ncbi.nlm.nih.gov/pubmed/17515956
               PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr469</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re217"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s253" id="s253" name="CDKN1A" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr73</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re87"/>
<celldesigner:catalyzed reaction="re88"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s854" id="s854" name="CDKN1B" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr471</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s852" id="s852" name="CDKN1B" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956
PMID: 17515956
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/16817978
PMID: 16817978
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s133" id="s133" name="ECSIT " compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s1080" id="s1080" name="EGF" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<annotation>
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</annotation>
</species>
<species metaid="s1081" id="s1081" name="EGFR" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s872" id="s872" name="ELK1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
<species metaid="s871" id="s871" name="ELK1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:name>EMT</celldesigner:name>
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</annotation>
</species>
<species metaid="s873" id="s873" name="EPHA4" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s874" id="s874" name="EPHB3" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s875" id="s875" name="ETS1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</species>
<species metaid="s1243" id="s1243" name="F11R/MLLT4/CGN" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</species>
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<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s130" id="s130" name="FADD" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/19191904
PMID: 19191904
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<annotation>
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<annotation>
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</species>
<species metaid="s1028" id="s1028" name="FGF1" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<annotation>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s1029" id="s1029" name="FGFR1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s1074" id="s1074" name="FN1" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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PMID: 17134501
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
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<notes>
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<body>PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/18205922
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
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PMID: 17665400
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PMID: 18388148
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PMID: 19290479
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PMID: 12905466
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PMID: 18452992
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PMID: 12905466
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PMID: 18452992
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PMID: 12905466
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PMID: 17134501
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PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
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PMID: 17134501
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PMID: 19563633 
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PMID: 17665400
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PMID: 17665400
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PMID: 17134501
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PMID: 17134501
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PMID: 19710928
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PMID: 17134501
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PMID: 19710928
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PMID: 17134501
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PMID: 17594488
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PMID: 15479887
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PMID: 19710928
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</notes>
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PMID: 19710928
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PMID: 12905466
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PMID: 12905466
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PMID: 12905466
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PMID: 17515956
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PMID: 17515956
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PMID: 17515956
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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PMID: 17515956
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
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<body>KEGG
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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PMID: 18452992
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PMID: 18452992
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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PMID: 18452992
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PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
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</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr564</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s919" id="s919" name="MEF2C" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr513</celldesigner:proteinReference>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
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</celldesigner:state>
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</annotation>
</species>
<species metaid="s918" id="s918" name="MEF2C" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr513</celldesigner:proteinReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s1078" id="s1078" name="MET" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr410</celldesigner:proteinReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s909" id="s909" name="MICB" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr508</celldesigner:proteinReference>
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</species>
<species metaid="s1202" id="s1202" name="MICB/KLRK1/HCST" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MICB/KLRK1/HCST</celldesigner:name>
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<celldesigner:catalyzed reaction="re208"/>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s354" id="s354" name="MIR146A" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn31</celldesigner:rnaReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s352" id="s352" name="MIR146A" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn44</celldesigner:geneReference>
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</annotation>
</species>
<species metaid="s250" id="s250" name="MIR155" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn37</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s244" id="s244" name="MIR155" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ANTISENSE_RNA</celldesigner:class>
<celldesigner:antisensernaReference>arn1</celldesigner:antisensernaReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re84"/>
<celldesigner:catalyzed reaction="re85"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s341" id="s341" name="MIR346" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn28</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re104"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s340" id="s340" name="MIR346" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn41</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s249" id="s249" name="MMP1" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn25</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s248" id="s248" name="MMP1" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn36</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s247" id="s247" name="MMP3" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn24</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s246" id="s246" name="MMP3" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn35</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s955" id="s955" name="MSN" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr533</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s779" id="s779" name="MYD88" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1106" id="s1106" name="MYL12B" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr565</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re296"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s947" id="s947" name="MYL6,9" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr529</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s946" id="s946" name="MYL6,9" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr529</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s234" id="s234" name="NAMPT" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn23</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s233" id="s233" name="NAMPT" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn34</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1188" id="s1188" name="NCF/CYBB/CYBA" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04670+4689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>NCF/CYBB/CYBA</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re311"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s922" id="s922" name="NFAT5" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr514</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s921" id="s921" name="NFAT5" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr514</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re262"/>
<celldesigner:catalyzed reaction="re308"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s334" id="s334" name="NFKB1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re106"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s176" id="s176" name="NFKB1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr17</celldesigner:proteinReference>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:class>GENE</celldesigner:class>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<species metaid="s1180" id="s1180" name="NLK" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19842941
PMID: 19842941
</body>
</html>
</notes>
<annotation>
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<species metaid="s1179" id="s1179" name="NLK" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19842941
PMID: 19842941
</body>
</html>
</notes>
<annotation>
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<species metaid="s440" id="s440" name="NRAS" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<species metaid="s732" id="s732" name="NRF1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<species metaid="s937" id="s937" name="PARD3" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr522</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s467" id="s467" name="PARD6A" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</species>
<species metaid="s466" id="s466" name="PARD6A" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PARVG/ILK</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s302" id="s302" name="PDE4B" compartment="c9" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr117</celldesigner:proteinReference>
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</species>
<species metaid="s225" id="s225" name="PDE4B" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:geneReference>gn31</celldesigner:geneReference>
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</species>
<species metaid="s224" id="s224" name="PDE4B" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
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</species>
<species metaid="s1108" id="s1108" name="PDE3A" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
<species metaid="s1107" id="s1107" name="PDE3A" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<annotation>
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<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:catalyzed reaction="re207"/>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s1049" id="s1049" name="PDGFRA" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:proteinReference>pr326</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PDIA3/HLA-A/B2M</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s172" id="s172" name="PELI1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
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<species metaid="s173" id="s173" name="PELI2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</species>
<species metaid="s1010" id="s1010" name="PERP" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species metaid="s1009" id="s1009" name="PERP" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
<species metaid="s948" id="s948" name="PHKA2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
<species metaid="s821" id="s821" name="PHKA2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:name>PIK3AP1/PIK3R5</celldesigner:name>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<species metaid="s929" id="s929" name="PIP4K2B" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<species metaid="s956" id="s956" name="PRKCD" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/16817978
PMID: 16817978
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633
</body>
</html>
</notes>
<annotation>
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<annotation>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19191904
PMID: 19191904
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19191904
PMID: 19191904
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
<species metaid="s178" id="s178" name="RUNX1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/15479887
PMID: 15479887
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
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PMID: 19563633
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PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/17911418
PMID: 17911418
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
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PMID: 19290479
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PMID: 18454843
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PMID: 18454843
</body>
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PMID: 18454843
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18388148
PMID: 18388148
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/17568789
PMID: 17568789
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17652167 
PMID: 17652167
http://www.ncbi.nlm.nih.gov/pubmed/19842941
PMID: 19842941
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
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PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
http://www.ncbi.nlm.nih.gov/pubmed/18281366
PMID: 18281366
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</species>
<species metaid="s722" id="s722" name="TNFRSF10B" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</species>
<species metaid="s1001" id="s1001" name="TNFRSF1A,B" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</species>
<species metaid="s1163" id="s1163" name="TNNC1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
<annotation>
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</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/15479887
PMID: 15479887
</body>
</html>
</notes>
<annotation>
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<annotation>
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/15479887
PMID: 15479887
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19842941
PMID: 19842941
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19842941
PMID: 19842941
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<species metaid="s1121" id="s1121" name="TXK" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18250114
PMID: 18250114
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18042642 
PMID: 18042642 
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18042642 
PMID: 18042642 
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
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<species metaid="s771" id="s771" name="UQCRC1" compartment="c7" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<species metaid="s707" id="s707" name="YWHAQ" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<species metaid="s463" id="s463" name="YWHAQ" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species metaid="s932" id="s932" name="ZAP70" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</celldesigner:extension>
</annotation>
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<species metaid="s774" id="s774" name="ZAP70" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species metaid="s208" id="s208" name="ZFP36" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/19710928
PMID: 19710928
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species metaid="s1109" id="s1109" name="active_cAMP" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s954" id="s954" name="cAMP" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s346" id="s346" name="unknown TF" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s344" id="s344" name="unknown TF" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s1249" id="s1249" name="VEGFA" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn82</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1250" id="s1250" name="VEGFA" compartment="c10" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn50</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1251" id="s1251" name="IFNB1" compartment="c10" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn51</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1252" id="s1252" name="CCND1" compartment="c10" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn52</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1257" id="s1257" name="CD3G" compartment="c2" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19884985
PMID: 19884985
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr593</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1258" id="s1258" name="CXCR4" compartment="c2" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19884985
PMID: 19884985
http://www.ncbi.nlm.nih.gov/pubmed/19877080
PMID: 19877080
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr594</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1259" id="s1259" name="CXCL12" compartment="default" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19884985
PMID: 19884985
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr595</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1254" id="s1254" name="CXCR4/CXCL12" compartment="c2" initialAmount="0" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>CXCR4/CXCL12</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re200"/>
<celldesigner:catalyzed reaction="re304"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1261" id="s1261" name="PKD2L1" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr585</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1262" id="s1262" name="CD72" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19884985
PMID: 19884985
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr596</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1265" id="s1265" name="CD72/PTPN6" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>CD72/PTPN6</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re194"/>
<celldesigner:catalyzed reaction="re241"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1266" id="s1266" name="PTPN6" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17665400
PMID: 17665400
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr414</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1267" id="s1267" name="NOD2" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19703281
PMID: 19703281
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr597</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re342"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1268" id="s1268" name="MDP" compartment="c2" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>MDP</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re341"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1278" id="s1278" name="JUP" compartment="c10" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19703281
PMID: 19703281
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn84</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1279" id="s1279" name="JUP" compartment="c10" initialAmount="0" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19703281
PMID: 19703281
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn53</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1269" id="s1269" name="RUNX1" compartment="c6" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr60</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re343"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s862" id="s862" name="PIK3R5" compartment="c2" charge="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+118788
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr138</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re119"/>
<celldesigner:catalyzed reaction="re274"/>
<celldesigner:catalyzed reaction="re307"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1281" id="s1281" name="PARVG" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg/
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr515</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1283" id="s1283" name="PIK3AP1" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17134501
PMID: 17134501
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr517</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1285" id="s1285" name="BLNK" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
http://www.ncbi.nlm.nih.gov/pubmed/12905466 
PMID: 12905466
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr407</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1287" id="s1287" name="CDK7" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
http://www.ncbi.nlm.nih.gov/pubmed/15496955
PMID: 15496955
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr543</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1288" id="s1288" name="CCNH" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr542</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1289" id="s1289" name="ADCY7" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19563633
PMID: 19563633 
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>outerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr532</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re1" id="re1" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+3725
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s4" alias="sa2">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s5" alias="sa3">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s159" aliases="sa117" targetLineIndex="-1,4" editPoints="0.04466876116167984,0.018594110064598324 0.19235570978826266,-0.3361952835648505">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s159" alias="sa117">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s168" aliases="sa127" targetLineIndex="-1,2" editPoints="0.3018630978480915,-0.8928372694548008 1.199281300881521,-0.5894253845562694">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s168" alias="sa127">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,3" editPoints="-1.904999658584039E-4,-0.020186782890600607 0.9997204535235273,-0.029622808607690176">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00001" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00002" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00003" species="s159">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00004" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa127</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00005" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re3" id="re3" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+7189
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s18" alias="sa10">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s44" alias="sa11">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.22426664353906212,0.03698638362031614 0.250745531812699,-0.12356814527696347</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s15" aliases="sa9" targetLineIndex="-1,3" editPoints="0.18179436173078045,-0.3856749561141868">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s15" alias="sa9">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00006" species="s1237">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00007" species="s44">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00008" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17515956 
PMID: 17515956
http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/18454843
PMID: 18454843
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+3665
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
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</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992 
PMID: 18452992
http://www.ncbi.nlm.nih.gov/pubmed/17875202
PMID: 17875202
</body>
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</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992 
PMID: 18452992
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+8772
</body>
</html>
</notes>
<annotation>
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<celldesigner:extension>
<celldesigner:alias>sa94</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00059" species="s1237">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00060" species="s389">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa315</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re35" id="re35" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+8772
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s131" alias="sa96">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s131" alias="sa95">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s130" aliases="sa94" targetLineIndex="-1,3" editPoints="0.7033262851377433,0.456791442314854">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s130" alias="sa94">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00061" species="s131">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa96</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00062" species="s131">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa95</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00063" species="s130">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa94</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re37" id="re37" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992 
PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s312" alias="csa15">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s140" alias="csa16">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s29" aliases="csa5" targetLineIndex="-1,2" editPoints="0.00953823248785235,-0.03314812295497427 0.9330718354465697,0.23259477377945925">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s29" alias="csa5">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s241" aliases="sa197" targetLineIndex="-1,4" editPoints="0.032933625295400226,-0.08542572516510383 0.9035372261906645,0.2502124297032955">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s241" alias="sa197">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1241" aliases="sa313" targetLineIndex="-1,5" editPoints="-0.012755462083609614,-0.07289311822340072 0.9575333272917821,-0.24268256014435344">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00064" species="s312">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00065" species="s140">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00066" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00067" species="s241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa197</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00068" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re39" id="re39" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992 
PMID: 18452992
KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+4792
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s151" alias="sa108">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s152" alias="sa109">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s140" aliases="csa16" targetLineIndex="-1,3" editPoints="0.2427711413372169,-0.05542913403510319 0.2923176370559766,0.16157694993663485">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s140" alias="csa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00069" species="s151">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa108</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00070" species="s152">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa109</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00071" species="s140">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re40" id="re40" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+4790
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s152" alias="sa109">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s176" alias="sa27">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s314" alias="sa31">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="vertical"/>
<celldesigner:lineDirection arm="2" index="0" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.20534636389768224,0.2535977771390261</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00072" species="s152">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa109</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00073" species="s176">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa27</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00074" species="s313">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re41" id="re41" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+4214
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s155" alias="sa113">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s156" alias="sa114">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s154" aliases="sa112" targetLineIndex="-1,2" editPoints="0.037539557826352876,-0.1285178872349788 0.9589267477347452,0.14061560414264163">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s154" alias="sa112">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,4" editPoints="0.0017916148052363745,0.029328449656886968 0.9980737515134912,-0.03153238162473179">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s36" aliases="sa21" targetLineIndex="-1,3" editPoints="-0.0067335806260055975,-0.033983684316083146 0.9554894633087183,-0.22464007066523847">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s36" alias="sa21">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00075" species="s155">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa113</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00076" species="s156">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa114</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00077" species="s154">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa112</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00078" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00079" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re42" id="re42" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+6416
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s157" alias="sa115">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s158" alias="sa116">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s156" aliases="sa114" targetLineIndex="-1,2" editPoints="0.07329332953039369,-0.16723580971547447 0.9121668764097968,0.20041173784247235">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s156" alias="sa114">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,2" editPoints="0.28257487266267267,0.28165790374192023 0.7809497162781884,-0.21833945511783015">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00080" species="s157">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa115</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00081" species="s158">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa116</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00082" species="s156">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa114</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00083" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re43" id="re43" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5879
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s159" alias="sa117">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s158" aliases="sa116" targetLineIndex="-1,3" editPoints="0.2342480710833894,-0.5705415349714911 1.0899956265454,-0.21919601161477642">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s158" alias="sa116">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkAnchor position="E"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s951" aliases="sa897" targetLineIndex="-1,4" editPoints="0.013176382932331698,0.18581322647398812 1.0081730340676776,0.11525604849192406">
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<celldesigner:linkTarget species="s951" alias="sa897">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00084" species="s242">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00085" species="s159">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00086" species="s158">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa116</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00087" species="s370">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa301</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00088" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00089" species="s951">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa897</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re47" id="re47" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04912+5606
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s163" alias="sa125">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s164" alias="sa126">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s29" alias="csa5">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s156" alias="sa114">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00090" species="s163">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa125</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00091" species="s164">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa126</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00092" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa5</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00093" species="s156">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa114</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00094" species="s370">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa301</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00095" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re48" id="re48" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+1432
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s168" alias="sa127">
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s164" alias="sa126">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s444" aliases="sa371" targetLineIndex="-1,4" editPoints="0.13428919211206003,-0.13505302373649908 0.6371250842837799,0.3649389339144119">
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</annotation>
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<speciesReference metaid="CDMT00096" species="s166">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa128</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00097" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa127</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00098" species="s164">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa126</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00099" species="s444">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa371</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re49" id="re49" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+3725
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</annotation>
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<celldesigner:alias>sa3</celldesigner:alias>
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</annotation>
</speciesReference>
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<celldesigner:alias>csa7</celldesigner:alias>
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</annotation>
</speciesReference>
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</reaction>
<reaction metaid="re50" id="re50" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992 PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
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</annotation>
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<speciesReference metaid="CDMT00103" species="s172">
<annotation>
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<celldesigner:alias>sa129</celldesigner:alias>
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</reaction>
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<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseProducts>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re53" id="re53" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18205922
PMID: 18205922
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa142</celldesigner:alias>
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
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</html>
</notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>PMID: 18454843
http://www.ncbi.nlm.nih.gov/pubmed/18454843
</body>
</html>
</notes>
<annotation>
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<annotation>
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<annotation>
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</annotation>
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<reaction metaid="re68" id="re68" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<annotation>
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
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<notes>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
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</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<annotation>
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</modifierSpeciesReference>
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<reaction metaid="re77" id="re77" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+3446
http://www.ncbi.nlm.nih.gov/pubmed/18454843 PMID: 18454843
</body>
</html>
</notes>
<annotation>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00194" species="s226">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa179</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00195" species="s227">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa180</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00196" species="s211">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa166</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00197" species="s196">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa151</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00198" species="s200">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa155</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="re78" id="re78" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s228" alias="sa181">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s229" alias="sa182">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:extension>
</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa181</celldesigner:alias>
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</annotation>
</speciesReference>
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<speciesReference metaid="CDMT00200" species="s229">
<annotation>
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</annotation>
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<listOfModifiers>
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<annotation>
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</annotation>
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<modifierSpeciesReference metaid="CDMT00202" species="s222">
<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="re79" id="re79" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s229" alias="sa182">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</annotation>
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<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00204" species="s183">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00208" species="s233">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa186</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00209" species="s234">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa187</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00210" species="s196">
<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re82" id="re82" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18452992
PMID: 18452992
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:baseProducts>
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</annotation>
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<annotation>
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</listOfModifiers>
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<reaction metaid="re83" id="re83" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04621+257397
</body>
</html>
</notes>
<annotation>
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<celldesigner:extension>
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</annotation>
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<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfModifiers>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="re84" id="re84" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392 PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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<annotation>
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<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re85" id="re85" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392 PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<annotation>
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</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392 PMID: 18383392
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<celldesigner:extension>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00224" species="s244">
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</modifierSpeciesReference>
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</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04110+890
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re88" id="re88" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+894
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+1326
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+1326
</body>
</html>
</notes>
<annotation>
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00243" species="s319">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa269</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00244" species="s320">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa270</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00245" species="s315">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa265</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00246" species="s452">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa358</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00247" species="s956">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa917</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re96" id="re96" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5594
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s323" alias="sa271">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s324" alias="sa272">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s320" aliases="sa270" targetLineIndex="-1,2" editPoints="0.045821981765962416,-0.04658895113902339 0.5541209624360088,0.45334217103665786">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s320" alias="sa270">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s952" aliases="sa911" targetLineIndex="-1,4" editPoints="0.33434349933055596,0.11300124179709381 0.43686283127833725,-0.1903288070354645">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s952" alias="sa911">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s455" aliases="sa378" targetLineIndex="-1,5" editPoints="0.02031636695099026,-0.03633055117236572 0.7820965885743831,0.3896637158862508">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s455" alias="sa378">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00248" species="s323">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa271</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00249" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00250" species="s320">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa270</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00251" species="s952">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa911</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00252" species="s455">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa378</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re97" id="re97" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+2353
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s325" alias="sa273">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s325" alias="sa274">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
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<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s796" aliases="sa761" targetLineIndex="-1,7">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s796" alias="sa761">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s159" aliases="sa117" targetLineIndex="-1,2" editPoints="0.00440255720509064,0.018978619757626936 0.9533382383692868,-0.20115032921919243">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s159" alias="sa117">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s168" aliases="sa372" targetLineIndex="-1,6" editPoints="0.03530198721667255,-0.17225752237615943 0.9949955424988,0.024419459581764724">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s168" alias="sa372">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00253" species="s325">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa273</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00254" species="s325">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa274</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00255" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00256" species="s796">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa761</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00257" species="s159">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00258" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa372</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re99" id="re99" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04210+4790
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s332" alias="sa280">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s333" alias="sa281">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s314" aliases="sa31" targetLineIndex="-1,2" editPoints="0.4260497045742111,0.22201491209238733 0.6396056195501312,-0.18780185934909177">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s314" alias="sa31">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00259" species="s332">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa280</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00260" species="s333">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa281</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00261" species="s313">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re101" id="re101" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s176" alias="sa266">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s334" alias="sa282">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.03280877093032686,-0.061521617116514715 0.8113844700984312,0.3536838498910879</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00262" species="s176">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa266</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00263" species="s334">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa282</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re102" id="re102" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s340" alias="sa283">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s341" alias="sa284">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00264" species="s340">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa283</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00265" species="s341">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa284</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re104" id="re104" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s344" alias="sa286">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s346" alias="sa287">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s341" aliases="sa284" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s341" alias="sa284">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00266" species="s344">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa286</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00267" species="s346">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa287</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00268" species="s341">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa284</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re105" id="re105" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19342689
PMID: 19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s348" alias="sa288">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s350" alias="sa289">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s346" aliases="sa287" targetLineIndex="-1,2" editPoints="0.0183885595401998,-0.09053160100809521 0.9787664869626598,0.10453803769100922">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s346" alias="sa287">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00269" species="s348">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa288</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00270" species="s350">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa289</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00271" species="s346">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa287</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re106" id="re106" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s352" alias="sa290">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa290</celldesigner:alias>
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<annotation>
<celldesigner:extension>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa292</celldesigner:alias>
</celldesigner:extension>
</annotation>
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<listOfProducts>
<speciesReference metaid="CDMT00276" species="s360">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa294</celldesigner:alias>
</celldesigner:extension>
</annotation>
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<modifierSpeciesReference metaid="CDMT00277" species="s354">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa291</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re108" id="re108" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18383392
PMID: 18383392
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</annotation>
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<speciesReference metaid="CDMT00278" species="s361">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa293</celldesigner:alias>
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</annotation>
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<listOfProducts>
<speciesReference metaid="CDMT00279" species="s362">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa295</celldesigner:alias>
</celldesigner:extension>
</annotation>
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</listOfProducts>
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<modifierSpeciesReference metaid="CDMT00280" species="s354">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa291</celldesigner:alias>
</celldesigner:extension>
</annotation>
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</listOfModifiers>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s36" alias="sa72">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<speciesReference metaid="CDMT00281" species="s360">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa294</celldesigner:alias>
</celldesigner:extension>
</annotation>
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<listOfProducts>
<speciesReference metaid="CDMT00282" species="s36">
<annotation>
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<celldesigner:alias>sa72</celldesigner:alias>
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</annotation>
</speciesReference>
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</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s18" alias="sa10">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<celldesigner:extension>
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<speciesReference metaid="CDMT00284" species="s1237">
<annotation>
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<celldesigner:alias>csa1</celldesigner:alias>
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</listOfProducts>
</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+4217
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+7186
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04670+4689
</body>
</html>
</notes>
<annotation>
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<annotation>
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<celldesigner:alias>sa304</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00296" species="s438">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa305</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00297" species="s1199">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00298" species="s996">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa941</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00299" species="s1136">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1046</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re118" id="re118" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+23533
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseReactant species="s383" alias="sa310"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s862" alias="sa311">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s380" aliases="sa308" targetLineIndex="-1,2" editPoints="0.10501350967561578,-0.1813235916982976 0.8538447266341436,0.2523618074874925">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s380" alias="sa308">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s861" aliases="sa824" targetLineIndex="-1,3" editPoints="0.4201320600861095,-0.26091909954079817 0.6984707215623707,0.1872619475862134">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s861" alias="sa824">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,2" editPoints="0.00784198996924923,-0.13120824378180548 1.0042825496392862,-0.07165347307029363">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s789" alias="sa753">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s724" aliases="sa302" targetLineIndex="-1,2" editPoints="0.09495019036083518,0.13387128928855022 0.7602611634179341,-0.33801035073033747">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s724" alias="sa302">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s881" aliases="sa845" targetLineIndex="-1,3" editPoints="0.6608471998767509,-0.13357352087795094 0.7000980135794652,0.060617589439666775">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s881" alias="sa845">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s884" aliases="sa847" targetLineIndex="-1,2" editPoints="0.06641857548315633,-0.20629267728457634 0.972494666338967,0.08543015081645478">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s884" alias="sa847">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s792" aliases="sa757" targetLineIndex="-1,2" editPoints="0.0022732358670871644,-0.05438342295271177 1.0005290299283196,-0.01265616945561493">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s792" alias="sa757">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,2" editPoints="0.018278632927905658,-0.10184727252127657 0.9870738891931609,0.07202339120091028">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s932" aliases="sa735" targetLineIndex="-1,4" editPoints="2.6768159401058256E-4,-0.02019060837360509 1.0000919451309707,-0.00693521023791531">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s932" alias="sa735">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s770" aliases="sa731" targetLineIndex="-1,2" editPoints="0.19569961931920454,0.15648150896926966 0.5857058186762837,-0.33126982503211005">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s770" alias="sa731">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s440" aliases="sa331" targetLineIndex="-1,5" editPoints="-0.042601489632815515,-0.05765996431197383 0.6042773321475274,-0.5355999309525741">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s440" alias="sa331">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s977" aliases="sa922" targetLineIndex="-1,4" editPoints="-0.012083411853876319,-0.03625646661225479 0.8879475214218985,-0.33621521781400343">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s977" alias="sa922">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1203" aliases="csa42" targetLineIndex="-1,5" editPoints="0.03466648072049128,-0.15567962695780302 0.9874234158652884,0.05647870466810828">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1203" alias="csa42">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s996" aliases="sa941" targetLineIndex="-1,4" editPoints="0.08349170452609478,0.24030826632089528 0.9757818739619131,-0.06970531880726813">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s996" alias="sa941">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1114" aliases="sa1020" targetLineIndex="-1,6" editPoints="0.004395397223826869,0.036768520169259716 0.9903063492492544,-0.08108964332289173">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1114" alias="sa1020">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00300" species="s383">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa310</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00301" species="s862">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa311</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00302" species="s380">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa308</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00303" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa824</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00304" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00305" species="s1199">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00306" species="s881">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa845</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00307" species="s1202">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00308" species="s792">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa757</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00309" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00310" species="s932">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa735</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00311" species="s770">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa731</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00312" species="s440">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa331</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00313" species="s977">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa922</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00314" species="s1203">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00315" species="s996">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa941</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00316" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1020</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re119" id="re119" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04510+208
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1240" alias="sa312">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1241" alias="sa313">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s862" aliases="sa311" targetLineIndex="-1,2" editPoints="0.13136645153797255,-0.08037412456298765 0.4037432506200776,0.3648086226362848">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s862" alias="sa311">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s387" aliases="sa314" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s387" alias="sa314">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s895" aliases="sa858" targetLineIndex="-1,4" editPoints="0.06258390024728033,0.038097786340798356 0.3329622650555907,-0.40605748454078716">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s895" alias="sa858">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00317" species="s1240">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa312</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00318" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00319" species="s862">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa311</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00320" species="s387">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa314</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00321" species="s895">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa858</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re120" id="re120" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s466" alias="sa318">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s467" alias="sa319">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s1000" aliases="sa316" targetLineIndex="-1,2" editPoints="0.004407043779091513,-0.06623912547898753">
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<annotation>
<celldesigner:extension>
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</annotation>
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</annotation>
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<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re125" id="re125" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa325</celldesigner:alias>
</celldesigner:extension>
</annotation>
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<listOfProducts>
<speciesReference metaid="CDMT00329" species="s402">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa326</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</listOfProducts>
</reaction>
<reaction metaid="re128" id="re128" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+3265
</body>
</html>
</notes>
<annotation>
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<celldesigner:linkTarget species="s1114" alias="sa1020">
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<annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa331</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00334" species="s870">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa328</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00335" species="s940">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa898</celldesigner:alias>
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</annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re140" id="re140" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+9261
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s425" alias="sa356">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00337" species="s410">
<annotation>
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<celldesigner:alias>sa341</celldesigner:alias>
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</annotation>
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<speciesReference metaid="CDMT00338" species="s425">
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<annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa356</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00341" species="s411">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa343</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re142" id="re142" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5894
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkTarget species="s440" alias="sa331">
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<celldesigner:linkTarget species="s463" alias="sa385">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s930" alias="sa891">
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s951" aliases="sa897" targetLineIndex="-1,2" editPoints="-0.011095882781681166,0.13368461522672337 0.9820621776934865,0.2161171778968921">
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</celldesigner:extension>
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<annotation>
<celldesigner:extension>
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<celldesigner:extension>
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</modifierSpeciesReference>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</speciesReference>
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<speciesReference metaid="CDMT00349" species="s735">
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<celldesigner:extension>
<celldesigner:alias>sa364</celldesigner:alias>
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</annotation>
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</listOfProducts>
</reaction>
<reaction metaid="re148" id="re148" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+5879
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s864" aliases="sa826" targetLineIndex="-1,3" editPoints="0.6070810349022902,0.008356005963725766 0.6072704531784101,-0.005405621732032184">
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<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="INHIBITION" modifiers="s944" aliases="sa904" targetLineIndex="-1,5" editPoints="0.023772552936947022,-0.11162627999646668 0.9803859926240963,0.09209943437722279">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s980" alias="sa926">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s1093" aliases="sa999" targetLineIndex="-1,7" editPoints="0.9060308349215845,-0.2917858137279483">
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<celldesigner:linkTarget species="s1093" alias="sa999">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00350" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa332</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00351" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00352" species="s440">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa331</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00353" species="s765">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa725</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00354" species="s864">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa826</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00355" species="s1204">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00356" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa421</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00357" species="s944">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa904</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00358" species="s980">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa926</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00359" species="s1185">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re149" id="re149" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04912+5606
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s443" alias="sa369">
<celldesigner:linkAnchor position="E"/>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
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<celldesigner:linkTarget species="s156" alias="sa114">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s959" aliases="sa918" targetLineIndex="-1,7" editPoints="0.038386808503585,-0.24768481983275104 1.014930645270173,-0.09633763076146717">
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<celldesigner:line width="1.0" color="ff000000"/>
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<listOfProducts>
<speciesReference metaid="CDMT00361" species="s444">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa371</celldesigner:alias>
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<modifierSpeciesReference metaid="CDMT00362" species="s156">
<annotation>
<celldesigner:extension>
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<modifierSpeciesReference metaid="CDMT00363" species="s370">
<annotation>
<celldesigner:extension>
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<modifierSpeciesReference metaid="CDMT00364" species="s764">
<annotation>
<celldesigner:extension>
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<modifierSpeciesReference metaid="CDMT00365" species="s959">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa918</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="re151" id="re151" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<annotation>
<celldesigner:extension>
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</listOfModifiers>
</reaction>
<reaction metaid="re152" id="re152" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+9252
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5605
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 
PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04666+6198
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04910+2308
</body>
</html>
</notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
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</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<annotation>
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</modifierSpeciesReference>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04115+4193
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s711" alias="sa695">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00426" species="s719">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa702</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00427" species="s721">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa704</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00428" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re179" id="re179" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s720" alias="sa703">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s722" alias="sa705">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s711" aliases="sa695" targetLineIndex="-1,2" editPoints="0.5971641412393045,0.32467491707721907 0.8253232523634084,-0.09497080390080181">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s711" alias="sa695">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00429" species="s720">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa703</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00430" species="s722">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa705</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00431" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re187" id="re187" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+10663
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s743" alias="sa707">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s745" alias="sa708">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s746" aliases="sa709" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s746" alias="sa709">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s266" aliases="sa223" targetLineIndex="-1,2" editPoints="0.9989273897632651,-0.032733159701055614">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s266" alias="sa223">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00432" species="s743">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa707</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00433" species="s1206">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00434" species="s746">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa709</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00435" species="s266">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa223</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re188" id="re188" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+387
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s335" alias="sa710">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s335" alias="sa421">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s748" aliases="sa711" targetLineIndex="-1,7" editPoints="0.31328832252680705,-0.2523445784058129 0.7067804151689332,0.23617979731176142">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s748" alias="sa711">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s749" aliases="sa712" targetLineIndex="-1,4" editPoints="0.6024222577481915,0.2595889870231609 0.7590260128983211,-0.1038377855500876">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s749" alias="sa712">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s765" aliases="sa725" targetLineIndex="-1,2" editPoints="0.995959274003344,-0.06343814727808358">
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<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s765" alias="sa725">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s930" aliases="sa891" targetLineIndex="-1,3" editPoints="0.015538092055757902,-0.11155306657454106 0.99650597319938,0.02508476606420801">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s930" alias="sa891">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1100" aliases="sa1005" targetLineIndex="-1,6" editPoints="0.8473481228804178,0.3596516113288666">
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<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1100" alias="sa1005">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s397" aliases="sa321" targetLineIndex="-1,5" editPoints="0.11800482130020651,0.13584084618836467 0.6879229038604233,-0.3592464811904552">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s397" alias="sa321">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s474" aliases="sa390" targetLineIndex="-1,7" editPoints="0.2017124152501264,0.23643449791231763 0.7804654125821671,-0.2573245176116723">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s474" alias="sa390">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00436" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa710</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00437" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa421</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00438" species="s748">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa711</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00439" species="s749">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa712</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00440" species="s765">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa725</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00441" species="s930">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa891</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00442" species="s1100">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1005</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00443" species="s397">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa321</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00444" species="s474">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa390</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re189" id="re189" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+596
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s753" alias="sa716">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s756" alias="sa717">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,2" editPoints="-0.06548406157167008,-0.5334864176524503 0.9196726608983088,-0.654411827067459">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1194" aliases="sa1054" targetLineIndex="-1,3" editPoints="0.2342225347345419,-0.20974040689715334 0.6792451862212263,0.28722789304806984">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1194" alias="sa1054">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1148" aliases="sa1056" targetLineIndex="-1,6" editPoints="0.0795881121711397,-0.2153638570363472 0.9594294392932485,0.10978313466143108">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1148" alias="sa1056">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00445" species="s753">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa716</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00446" species="s756">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa717</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00447" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00448" species="s1144">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00449" species="s1148">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1056</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re190" id="re190" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s756" alias="sa717">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s755" alias="sa719">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00450" species="s756">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa717</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00451" species="s755">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa719</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re191" id="re191" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04670+10451
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s762" alias="sa727">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s765" alias="sa725">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s912" aliases="sa729" targetLineIndex="-1,6" editPoints="0.5163509694485573,-0.2942679132166297 0.7615114461665712,0.13591439392001892">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s912" alias="sa729">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s769" aliases="sa730" targetLineIndex="-1,7" editPoints="0.047645098811170294,-0.22671492387026804 1.0053483293680765,-0.025449544985145955">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s769" alias="sa730">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s770" aliases="sa731" targetLineIndex="-1,3" editPoints="0.2110998884556059,0.4425476499302344 1.0257379274737344,0.05395672826218128">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s770" alias="sa731">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00452" species="s762">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa727</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00453" species="s765">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa725</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00454" species="s912">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa729</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00455" species="s1211">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00456" species="s770">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa731</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re192" id="re192" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04650+7305
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s772" alias="sa736">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s775" alias="sa733">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s911" aliases="sa734" targetLineIndex="-1,3" editPoints="0.999928074097407,0.008480609014548612">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s911" alias="sa734">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00457" species="s772">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa736</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00458" species="s775">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa733</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00459" species="s911">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa734</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re193" id="re193" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+7535
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s774" alias="sa737">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s932" alias="sa735">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s775" aliases="sa733" targetLineIndex="-1,2" editPoints="0.012845952480345701,-0.08116754496502265 0.9884103119594521,0.07322979954979303">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s775" alias="sa733">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00460" species="s774">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa737</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00461" species="s932">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa735</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00462" species="s775">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa733</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re194" id="re194" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+10451
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s765" alias="sa725">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s762" alias="sa727">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s766" aliases="sa728" targetLineIndex="-1,3" editPoints="0.333579366425482,0.15300013241523835 0.5073862017538397,-0.22594316060035124">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s766" alias="sa728">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1121" aliases="sa1027" targetLineIndex="-1,6" editPoints="0.943890827054672,0.24572178442044468 1.007360414440773,0.0019161264402836053">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1121" alias="sa1027">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00463" species="s765">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa725</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00464" species="s762">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa727</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00465" species="s1265">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00466" species="s1121">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1027</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re195" id="re195" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04666+6198
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s776" alias="sa738">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s777" alias="sa739">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1241" aliases="sa313" targetLineIndex="-1,2" editPoints="0.7310998675390055,-0.38837349959579126 0.9511858934125039,0.025930938093100098">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00467" species="s776">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa738</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00468" species="s777">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa739</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00469" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re196" id="re196" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+4615
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s779" alias="sa740">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s779" alias="sa54">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s780" aliases="sa741" targetLineIndex="-1,3" editPoints="0.018321628964976355,0.07821405612274146 0.9663030622194766,-0.14385042878928567">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s780" alias="sa741">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1065" aliases="sa856" targetLineIndex="-1,2" editPoints="0.01459736598090533,-0.13364304409290534 1.0028075882741145,-0.025704270482978686">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1065" alias="sa856">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00470" species="s779">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa740</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00471" species="s779">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00472" species="s780">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa741</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00473" species="s1213">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re197" id="re197" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04610+2159
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1220" alias="csa29">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1220" alias="csa28">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s787" aliases="sa751" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s787" alias="sa751">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00474" species="s1220">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00475" species="s1220">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00476" species="s787">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa751</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re198" id="re198" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04612+6890
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s788" alias="sa752">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1196" alias="csa27">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00477" species="s788">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa752</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00478" species="s1196">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa27</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re199" id="re199" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+6776
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s790" alias="sa754">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s791" alias="sa755">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,2" editPoints="0.2510862868663768,-0.26502521896999554 0.7780741996630844,0.23424590232871978">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s789" alias="sa753">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00479" species="s790">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa754</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00480" species="s791">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa755</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00481" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re200" id="re200" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+3717
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s792" alias="sa756">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s792" alias="sa757">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s745" aliases="sa708" targetLineIndex="-1,2" editPoints="0.0031466902456904755,0.04691561549425051 0.9986682804163252,-0.019855288908532012">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s745" alias="sa708">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1255" aliases="sa1105" targetLineIndex="-1,3" editPoints="0.8328515380515586,-0.37310836712235684">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1255" alias="sa1105">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00482" species="s792">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa756</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00483" species="s792">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa757</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00484" species="s1206">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00106" species="s1254">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re201" id="re201" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa05140+6772
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s793" alias="sa758">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s794" alias="sa759">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s792" aliases="sa757" targetLineIndex="-1,2" editPoints="0.05602364757099476,-0.10999513855230081 0.8500428309887251,0.294421379140005">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s792" alias="sa757">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00485" species="s793">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa758</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00486" species="s794">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa759</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00487" species="s792">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa757</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re203" id="re203" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04350+4086
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s800" alias="sa765">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s800" alias="sa764">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s799" aliases="sa763" targetLineIndex="-1,3" editPoints="0.3507897050918345,-0.2866303643383361 0.7511445242584927,0.20333987755059013">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s799" alias="sa763">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00490" species="s800">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa765</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00491" species="s800">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa764</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00492" species="s799">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa763</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re204" id="re204" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+4478
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s819" alias="sa769">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s819" alias="sa771">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s806" aliases="sa770" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s806" alias="sa770">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00493" species="s819">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa769</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00494" species="s819">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa771</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00495" species="s806">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa770</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re206" id="re206" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04930+2645
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s808" alias="sa773">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s808" alias="sa774">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s807" aliases="sa772" targetLineIndex="-1,2" editPoints="0.1495822382792561,0.23100484454064 0.8541582617943303,-0.22522826539633042">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s807" alias="sa772">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00496" species="s808">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa773</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00497" species="s808">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa774</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00498" species="s807">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa772</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re207" id="re207" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+25759
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s810" alias="sa776">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s811" alias="sa777">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
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<celldesigner:lineDirection index="1" value="horizontal"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s812" alias="sa778">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,3" editPoints="0.001360355004606184,-0.04435486512327383 1.0004206021143922,-0.013713883501934615">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s861" aliases="sa824" targetLineIndex="-1,6" editPoints="0.12078424848499845,-0.2581996884841708 0.9412424281169732,0.12560567248276644">
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<celldesigner:linkTarget species="s861" alias="sa824">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s933" aliases="sa782" targetLineIndex="-1,6" editPoints="0.0010022389725465874,0.004683767711734059 0.9572189670590762,-0.19992878570085967">
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<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s933" alias="sa782">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00499" species="s810">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa776</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00500" species="s811">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa777</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00501" species="s1203">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00502" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00503" species="s932">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa735</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00504" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa824</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00505" species="s1186">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re208" id="re208" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+2885
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s378" alias="sa779">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s378" alias="sa306">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s811" aliases="sa777" targetLineIndex="-1,3" editPoints="0.030595387923100903,-0.22027800505930428 1.0116688496684179,-0.08401236594078998">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s811" alias="sa777">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,2" editPoints="0.0029331910901368996,-0.04241133483931421 0.9981727798242912,0.026419978895247845">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s789" alias="sa753">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s724" aliases="sa302" targetLineIndex="-1,2" editPoints="0.02094293657549212,0.07108589765912697 0.9410773772196971,-0.19999905541754442">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s724" alias="sa302">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s933" aliases="sa782" targetLineIndex="-1,3" editPoints="0.0017062562164933404,0.011749807704775288 0.9810541677515913,-0.13046685695496116">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s933" alias="sa782">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s884" aliases="sa847" targetLineIndex="-1,2" editPoints="0.14430633151856487,-0.15648810809187985 0.6847386927434793,0.3418744348081435">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s884" alias="sa847">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s977" aliases="sa922" targetLineIndex="-1,4" editPoints="0.9866468876690744,-0.11478156089722485">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s977" alias="sa922">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1236" aliases="sa1023" targetLineIndex="-1,2" editPoints="0.30552782719276617,0.09863130762215988 0.3999066602872412,-0.1937237315993321">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1236" alias="sa1023">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00506" species="s378">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa779</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00507" species="s378">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa306</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00508" species="s811">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa777</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00509" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00510" species="s1199">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00511" species="s1186">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00512" species="s1202">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00513" species="s977">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa922</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00514" species="s1200">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re210" id="re210" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04722+27330
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s815" alias="sa783">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s816" alias="sa784">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,2" editPoints="0.009303506589207533,-0.02584103596728715 0.8945566082713943,0.2928752134525605">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s961" aliases="sa920" targetLineIndex="-1,2" editPoints="0.02469167025124719,-0.0780380339855884 0.9336896153660481,0.20957399791132358">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s961" alias="sa920">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00515" species="s815">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa783</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00516" species="s816">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa784</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00517" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00518" species="s961">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa920</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re211" id="re211" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04910+23433
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s817" alias="sa785">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s817" alias="sa787">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s857" aliases="sa786" targetLineIndex="-1,2" editPoints="0.0925343387328681,0.19760078474935572 0.912680477467319,-0.18646489954620993">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s857" alias="sa786">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00519" species="s817">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa785</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00520" species="s817">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa787</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00521" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re212" id="re212" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04020+5255
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s821" alias="sa789">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s948" alias="sa790">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s825" aliases="sa788" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s825" alias="sa788">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00522" species="s821">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa789</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00523" species="s948">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa790</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00524" species="s825">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa788</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re213" id="re213" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04720+11261
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s823" alias="sa791">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s823" alias="sa792">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s825" aliases="sa788" targetLineIndex="-1,2" editPoints="0.02758044829961115,-0.0835361769871481 0.9292882032302039,0.21417321088737484">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s825" alias="sa788">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00525" species="s823">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa791</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00526" species="s823">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa792</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00527" species="s825">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa788</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re214" id="re214" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04910+163688
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s825" alias="sa788">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s822" alias="sa793">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s826" aliases="sa794" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s826" alias="sa794">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00528" species="s825">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa788</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00529" species="s822">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa793</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00530" species="s826">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa794</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re215" id="re215" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04910+5834
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s827" alias="sa795">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s829" alias="sa796">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s825" aliases="sa788" targetLineIndex="-1,6">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s825" alias="sa788">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s948" aliases="sa790" targetLineIndex="-1,3" editPoints="0.359130267254983,0.18247664122836138 0.5643269030419731,-0.22136859701110456">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s948" alias="sa790">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00531" species="s827">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa795</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00532" species="s829">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa796</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00533" species="s825">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa788</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00534" species="s948">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa790</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re216" id="re216" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04370+842
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s831" alias="sa798">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s832" alias="sa799">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1241" aliases="sa313" targetLineIndex="-1,2" editPoints="0.009916945495121399,0.026278222642431404 0.8852535461994033,-0.30405862993649974">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00535" species="s831">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa798</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00536" species="s832">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa799</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00537" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re217" id="re217" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+983
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s848" alias="sa811">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s835" alias="sa802">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s849" aliases="sa812" targetLineIndex="-1,3" editPoints="0.22553906368686483,-0.059743490390914644 0.29110613302917154,0.1877803039403929">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s849" alias="sa812">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00538" species="s1183">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa31</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00539" species="s1182">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa30</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00540" species="s849">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa812</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re218" id="re218" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04012+1027
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s852" alias="sa815">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s854" alias="sa816">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1241" aliases="sa313" targetLineIndex="-1,2" editPoints="0.774948640220022,-0.1508994049121556 0.8114800776861107,0.0367089412314795">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00541" species="s852">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa815</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00542" species="s854">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa816</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00543" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re219" id="re219" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+1398
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s818" alias="sa819">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s857" alias="sa786">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,2" editPoints="0.4326956509742649,-0.17408018637109635 0.5720051238121197,0.17218899160392054">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s789" alias="sa753">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s380" aliases="sa308" targetLineIndex="-1,2" editPoints="0.0041695781590709025,0.02524139560788194 0.977607278419105,-0.1355589276893377">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s380" alias="sa308">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00544" species="s818">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa819</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00545" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00546" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00547" species="s380">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa308</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re220" id="re220" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04360+25
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s858" alias="sa820">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s858" alias="sa821">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s857" aliases="sa786" targetLineIndex="-1,2" editPoints="0.006575654505043715,-0.013677207107588796 0.8188281472544099,0.37683320347298244">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s857" alias="sa786">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s873" aliases="sa836" targetLineIndex="-1,5" editPoints="0.01921238495765243,-0.0726118354953933 0.9537848284444985,0.17466693707085912">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s873" alias="sa836">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00548" species="s858">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa820</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00549" species="s858">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa821</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00550" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00551" species="s873">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa836</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re221" id="re221" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04650+2185
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s863" alias="sa825">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s864" alias="sa826">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s861" aliases="sa824" targetLineIndex="-1,2" editPoints="0.9412380007940175,-0.23517871216438468">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s861" alias="sa824">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1211" aliases="csa32" targetLineIndex="-1,2" editPoints="0.13953848556480697,-0.28945394722473705 0.9509658371613536,0.10171482028816259">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1211" alias="csa32">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00552" species="s863">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa825</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00553" species="s864">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa826</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00554" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa824</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00555" species="s1211">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re222" id="re222" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+1445
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s861" alias="sa827">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s861" alias="sa824">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s769" aliases="sa730" targetLineIndex="-1,3" editPoints="0.08397147101655744,-0.27734502532382493">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s769" alias="sa730">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s781" aliases="sa742" targetLineIndex="-1,7" editPoints="0.06944029033442045,-0.2542013698088424">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s781" alias="sa742">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00556" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa827</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00557" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa824</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00558" species="s1211">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00559" species="s1212">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re223" id="re223" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+1616
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s865" alias="sa829">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s865" alias="sa828">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1000" aliases="sa316" targetLineIndex="-1,2" editPoints="0.10155248917488535,-0.28010134783333474 0.9853764608574522,0.040334540858646406">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1000" alias="sa316">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00560" species="s865">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa829</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00561" species="s865">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa828</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00562" species="s1215">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re224" id="re224" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+1649
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s866" alias="sa830">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s868" alias="sa831">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s168" aliases="sa372" targetLineIndex="-1,3" editPoints="0.9526252418404257,0.21243914528376395">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s168" alias="sa372">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00563" species="s866">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa830</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00564" species="s868">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa831</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00565" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa372</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re225" id="re225" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+6654
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s870" alias="sa833">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s870" alias="sa328">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s789" aliases="sa753" targetLineIndex="-1,2" editPoints="0.0030534599170879417,-0.04378022533686682 0.9982126168339531,0.025627334203715157">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s789" alias="sa753">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s724" aliases="sa302" targetLineIndex="-1,2" editPoints="0.007523364625317552,0.05125168963058524 0.9864298450628249,-0.09244445852572215">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s724" alias="sa302">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00566" species="s870">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa833</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00567" species="s870">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa328</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00568" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00569" species="s1199">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re226" id="re226" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+2002
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s871" alias="sa834">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s872" alias="sa835">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s159" aliases="sa117" targetLineIndex="-1,2" editPoints="0.23883479074632064,0.40805629748158573 0.9836724236964163,-0.027896146589317647">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s159" alias="sa117">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,3" editPoints="-0.009498757689878623,-0.05405991991292991 0.9605525724922055,-0.2245056502614875">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00570" species="s871">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa834</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00571" species="s872">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa835</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00572" species="s159">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00573" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re227" id="re227" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa05211+2113
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s875" alias="sa838">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s875" alias="sa839">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,2" editPoints="0.028488553593857713,-0.05772397167780241 0.8326233655515032,0.3391412650909107">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00574" species="s875">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa838</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00575" species="s875">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa839</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00576" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re228" id="re228" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04062+2309
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s879" alias="sa843">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s880" alias="sa844">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1241" aliases="sa313" targetLineIndex="-1,2" editPoints="-0.011335031432069265,-0.13418634108995398 0.9815799515171812,-0.21806017243287235">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00577" species="s879">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa843</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00578" species="s880">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa844</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00579" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re229" id="re229" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+10788
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s896" alias="sa859">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s896" alias="sa860">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,2" editPoints="0.15998777507307205,0.3155725202068457 0.9555169488138744,-0.0877418825462406">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00580" species="s896">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa859</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00581" species="s896">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa860</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00582" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re230" id="re230" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+3663
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s897" alias="sa861">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s897" alias="sa862">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s36" aliases="sa21" targetLineIndex="-1,2" editPoints="0.12228836576780333,-0.16614873078060355 0.7709138635296815,0.3112509564993877">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s36" alias="sa21">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00583" species="s897">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa861</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00584" species="s897">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa862</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00585" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re231" id="re231" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+3727
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s906" alias="sa868">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s907" alias="sa869">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s159" aliases="sa117" targetLineIndex="-1,2" editPoints="0.04047891121756386,-0.04000268508401961 0.5345619130247659,0.45996230282251993">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s159" alias="sa117">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00586" species="s906">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa868</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00587" species="s907">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa869</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00588" species="s159">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re232" id="re232" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+3932
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s911" alias="sa734">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s773" alias="sa873">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s910" aliases="sa871" targetLineIndex="-1,2" editPoints="0.023917406636859262,-0.1527918986616298">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s910" alias="sa871">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00589" species="s911">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa734</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00590" species="s773">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa873</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00591" species="s1219">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re233" id="re233" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+3937
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s767" alias="sa874">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s912" alias="sa729">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s932" aliases="sa735" targetLineIndex="-1,3" editPoints="0.08404365583761608,-0.27745327489698907">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s932" alias="sa735">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00592" species="s767">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa874</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00593" species="s912">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa729</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00594" species="s932">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa735</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re234" id="re234" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04650+3937
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s912" alias="sa729">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s767" alias="sa874">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s438" aliases="sa305" targetLineIndex="-1,3" editPoints="0.9797730049128102,0.14077593458021304">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s438" alias="sa305">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00595" species="s912">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa729</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00596" species="s767">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa874</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00597" species="s438">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa305</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re235" id="re235" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+7040
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s464" alias="sa745">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s464" alias="sa746">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s914" aliases="sa875" targetLineIndex="-1,2" editPoints="0.008893913019250022,0.039051325287197125 0.9595819565858692,-0.17746723600973446">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s914" alias="sa875">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s992" aliases="sa936" targetLineIndex="-1,2" editPoints="0.062072025664546615,0.15778298886003705 0.9280494259559058,-0.18289360627966245">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s992" alias="sa936">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00598" species="s464">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa745</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00599" species="s464">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa746</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00600" species="s914">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa875</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00601" species="s992">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa936</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re236" id="re236" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+4149
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s916" alias="sa877">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s917" alias="sa878">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s168" aliases="sa372" targetLineIndex="-1,3" editPoints="0.21177229975016765,0.2234039089157034 0.7384817224950702,-0.27588218816355026">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s168" alias="sa372">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00602" species="s916">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa877</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00603" species="s917">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa878</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00604" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa372</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re237" id="re237" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+4208
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s918" alias="sa879">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s919" alias="sa880">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s168" aliases="sa372" targetLineIndex="-1,3" editPoints="-0.1166570683355932,0.04222143573624404 -8.368313889159928E-4,0.36223066944723037">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s168" alias="sa372">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00605" species="s918">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa879</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00606" species="s919">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa880</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00607" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa372</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re238" id="re238" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+10725
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s922" alias="sa881">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s921" alias="sa882">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s823" aliases="sa792" targetLineIndex="-1,4" editPoints="0.30184590458795313,0.10654173195584704 0.41262971315011043,-0.2073225003526744">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s823" alias="sa792">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s825" aliases="sa788" targetLineIndex="-1,2" editPoints="0.3507876570534316,-0.2793472848659775 0.7388532696445216,0.2079623630124452">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s825" alias="sa788">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00608" species="s922">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa881</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00609" species="s921">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa882</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00610" species="s823">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa792</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00611" species="s825">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa788</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re240" id="re240" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+200576
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s929" alias="sa889">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s929" alias="sa890">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,2" editPoints="0.3714901909830832,0.2969908198854494 0.7614116287306611,-0.19074139161225334">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00612" species="s929">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa889</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00613" species="s929">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa890</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00614" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re241" id="re241" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+7535
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s932" alias="sa735">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s774" alias="sa737">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s766" aliases="sa728" targetLineIndex="-1,2" editPoints="0.004802434883120765,0.08243202002904298 1.0014197657544943,0.024369754501484014">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s766" alias="sa728">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00615" species="s932">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa735</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00616" species="s774">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa737</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00617" species="s1265">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re242" id="re242" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+2534
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s933" alias="sa782">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s814" alias="sa781">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.44396075766599097,0.23589994054199437 0.6641340355050822,-0.17846343327947878</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1219" aliases="csa52" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1219" alias="csa52">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00618" species="s1186">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00619" species="s814">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa781</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00620" species="s1219">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re243" id="re243" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04520+56288
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s937" alias="sa895">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s937" alias="sa896">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s935" aliases="sa893" targetLineIndex="-1,2" editPoints="0.4535502728982088,-0.4203399632008633 0.9156022393306902,0.07821790379990645">
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<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s935" alias="sa893">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00621" species="s937">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa895</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00622" species="s937">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa896</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00623" species="s1219">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re244" id="re244" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+25780
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s940" alias="sa899">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s940" alias="sa898">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
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<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s870" alias="sa328">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00624" species="s940">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa899</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00625" species="s940">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa898</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00626" species="s870">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa328</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re245" id="re245" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04110+5925
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s941" alias="sa900">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s942" alias="sa901">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1183" aliases="csa31" targetLineIndex="-1,2" editPoints="0.02596700111664818,-0.07974592952652082 0.9301020512087583,0.21466001689278547">
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<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="horizontal"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1183" alias="csa31">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1105" aliases="sa1006" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1105" alias="sa1006">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00627" species="s941">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa900</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00628" species="s942">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa901</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00629" species="s1183">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa31</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00630" species="s1105">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1006</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re246" id="re246" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04742+5330
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s943" alias="sa902">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s943" alias="sa903">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s881" aliases="sa845" targetLineIndex="-1,2" editPoints="0.06630177579385244,0.028497009596394923 0.22223087942560404,-0.3342911080044302">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s881" alias="sa845">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1114" aliases="sa1020" targetLineIndex="-1,2" editPoints="0.018181369005645154,-0.0483410540316116 0.894255546261584,0.281155855212267">
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<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1114" alias="sa1020">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00631" species="s943">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa902</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00632" species="s943">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa903</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00633" species="s881">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa845</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00634" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1020</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re247" id="re247" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04270+10398
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s947" alias="sa907">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s946" alias="sa906">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s945" aliases="sa905" targetLineIndex="-1,3" editPoints="0.25355036326985214,0.2989267761427534 0.835132679954441,-0.19437265179566765">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s945" alias="sa905">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1111" aliases="sa1017" targetLineIndex="-1,6" editPoints="0.28079016131543355,-0.3340187838683626 0.8667235354237626,0.15854131928084314">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1111" alias="sa1017">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00635" species="s947">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa907</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00636" species="s946">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa906</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00637" species="s945">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa905</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00638" species="s1111">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1017</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re248" id="re248" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04910+5256
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s948" alias="sa790">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s821" alias="sa789">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s826" aliases="sa794" targetLineIndex="-1,2" editPoints="0.09780535119674738,0.36391738353065106 1.030440781349185,0.11326506541486925">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s826" alias="sa794">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00639" species="s948">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa790</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00640" species="s821">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa789</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00641" species="s826">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa794</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re250" id="re250" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5906
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s939" alias="sa910">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s951" alias="sa897">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s952" aliases="sa911" targetLineIndex="-1,2" editPoints="0.07640274387180668,-0.055722065590026126 0.42362201838031166,0.42036411349763947">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s952" alias="sa911">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1110" aliases="sa1016" targetLineIndex="-1,3" editPoints="0.07428846129342137,0.2529317956843131 0.9948739283371058,-0.017452865329668124">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1110" alias="sa1016">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00642" species="s939">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa910</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00643" species="s951">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa897</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00644" species="s952">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa911</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00645" species="s1110">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1016</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re251" id="re251" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5568
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s952" alias="sa912">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s952" alias="sa911">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1109" aliases="sa914" targetLineIndex="-1,3" editPoints="0.4228813032213914,0.25508475880860715 0.6896671977551847,-0.18719476933122792">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1109" alias="sa914">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00646" species="s952">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa912</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00647" species="s952">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa911</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00648" species="s1109">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa914</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re253" id="re253" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+4478
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s955" alias="sa915">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s955" alias="sa916">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s806" aliases="sa770" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s806" alias="sa770">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00649" species="s955">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa915</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00650" species="s955">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa916</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00651" species="s806">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa770</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re254" id="re254" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+11072
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s324" alias="sa272">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s323" alias="sa271">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s666" aliases="sa627" targetLineIndex="-1,7" editPoints="0.025967202765798447,-0.10294359321162005 0.9661450929175119,0.13421336962435948">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s666" alias="sa627">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00652" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00653" species="s323">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa271</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00654" species="s666">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa627</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re255" id="re255" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+100137049
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s615" alias="sa919">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s960" alias="sa568">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,3" editPoints="0.03715321762716339,-0.15069182712181006 0.9798491937759204,0.08173078946637546">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1114" aliases="sa1020" targetLineIndex="-1,2" editPoints="0.06501797667004583,0.19385045506334686 0.9638984146081926,-0.10763652016157432">
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<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1114" alias="sa1020">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00655" species="s615">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa919</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00656" species="s960">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa568</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00657" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00658" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1020</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re256" id="re256" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+5829
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s978" alias="sa923">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s978" alias="sa924">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s857" aliases="sa786" targetLineIndex="-1,3" editPoints="-0.0036419642216145576,-0.036992966338084354 0.9867586392497012,-0.13449808474203895">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s857" alias="sa786">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00659" species="s978">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa923</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00660" species="s978">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa924</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00661" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re257" id="re257" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04520+1500
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s980" alias="sa926">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s981" alias="sa927">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s760" aliases="sa723" targetLineIndex="-1,2" editPoints="0.06444453540532846,-0.20978759681940096 0.9782161523529891,0.07091339891897952">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s760" alias="sa723">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00662" species="s980">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa926</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00663" species="s981">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa927</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00664" species="s1214">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re258" id="re258" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04110+1022
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s835" alias="sa802">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s848" alias="sa811">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1184" aliases="csa33" targetLineIndex="-1,3" editPoints="0.007537524602075685,-0.08649109968632018">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1184" alias="csa33">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00665" species="s1182">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa30</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00666" species="s1183">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa31</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00667" species="s1184">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa33</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re259" id="re259" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04350+4052
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s992" alias="sa938">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s992" alias="sa936">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s993" aliases="sa937" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s993" alias="sa937">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00668" species="s992">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa938</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00669" species="s992">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa936</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00670" species="s993">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa937</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re260" id="re260" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa05220+9846
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s995" alias="sa940">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s996" alias="sa941">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1187" aliases="sa962" targetLineIndex="-1,2" editPoints="0.003497071905241622,-0.0060746037005192655 0.7545772316634856,0.4263126687483525">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1187" alias="sa962">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s378" aliases="sa306" targetLineIndex="-1,2" editPoints="0.8414205510705742,-0.3652834615838299">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s378" alias="sa306">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00671" species="s995">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa940</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00672" species="s996">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa941</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00673" species="s1186">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00674" species="s378">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa306</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re261" id="re261" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+3479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s997" alias="sa942">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s997" alias="sa943">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s998" aliases="sa944" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s998" alias="sa944">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00675" species="s997">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa942</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00676" species="s997">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa943</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00677" species="s998">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa944</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re262" id="re262" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04370+5743
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1092" alias="sa945">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1092" alias="sa946">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s921" aliases="sa882" targetLineIndex="-1,3" editPoints="0.6820714796085596,0.46567153264200556">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s921" alias="sa882">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00678" species="s1092">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa945</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00679" species="s1092">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa946</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00680" species="s921">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa882</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re263" id="re263" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s722" alias="sa705">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1002" alias="sa948">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6870052628517769,0.12137732646752752 0.7172748178998631,-0.04995074795484289</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00681" species="s722">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa705</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00682" species="s1002">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa948</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re264" id="re264" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s721" alias="sa704">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1002" alias="sa948">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4817557888834686,-0.4446393837650886 0.9417545873856007,0.053757951579641805</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00683" species="s721">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa704</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00684" species="s1002">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa948</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
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<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+5054
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+118788
</body>
</html>
</notes>
<annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04510+3611
</body>
</html>
</notes>
<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+64065
</body>
</html>
</notes>
<annotation>
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<celldesigner:linkTarget species="s711" alias="sa695">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00710" species="s1009">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa956</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00711" species="s1010">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa957</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00712" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re277" id="re277" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04115+7057
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1011" alias="sa958">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1012" alias="sa959">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s711" alias="sa695">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00713" species="s1011">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa958</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00714" species="s1012">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa959</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00715" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re278" id="re278" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/17594488
PMID: 17594488
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1012" alias="sa959">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1013" alias="sa960">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.08446667121522472,-0.17021667583289046 0.8868774306342209,0.22796385180203327</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00716" species="s1012">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa959</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00717" species="s1013">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa960</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re279" id="re279" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1005" alias="sa951">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1013" alias="sa960">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5428657464869948,0.44205526477371865 0.9415730461527096,-0.04757703487468904</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00718" species="s1005">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa951</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00719" species="s1013">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa960</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re280" id="re280" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+2534
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s814" alias="sa781">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1022" alias="sa961">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1186" alias="csa38">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.6793791871832155,0.33952700958987503</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s833" alias="sa800">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s813" aliases="sa780" targetLineIndex="2,6" editPoints="0.39776337853399113,0.20771731237771718 0.6120363881246114,-0.20259974424020655">
<celldesigner:connectScheme connectPolicy="square">
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<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s813" alias="sa780">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00720" species="s814">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa781</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00721" species="s1022">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa961</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00722" species="s1186">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00723" species="s833">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa800</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00724" species="s813">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa780</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re281" id="re281" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+2246
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1028" alias="sa963">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1029" alias="sa964">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1199" alias="csa39">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.2384508990318115,0.25449515905947573</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00725" species="s1028">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa963</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00726" species="s1029">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa964</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00727" species="s1199">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re282" id="re282" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04621+3576
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s265" alias="sa967">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s266" alias="sa223">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1201" alias="csa40">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s979" alias="sa966" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s1242" alias="sa1085" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.9737115185057057,0.7380491179522682</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00728" species="s265">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa967</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00729" species="s266">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa223</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00730" species="s979">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa966</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00731" species="s1242">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1085</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00732" species="s1201">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re283" id="re283" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04650+10870
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s909" alias="sa968">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1041" alias="sa969">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1202" alias="csa41">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s1042" alias="sa970" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="NW"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.4261710486551804,0.3054699304925963</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00733" species="s909">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa968</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00734" species="s1041">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa969</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00735" species="s1042">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa970</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00736" species="s1202">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re284" id="re284" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+5154
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1048" alias="sa973">
<celldesigner:linkAnchor position="W"/>
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<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1203" alias="csa42">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00737" species="s1048">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa973</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00738" species="s1049">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa974</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00739" species="s1203">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re285" id="re285" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+3929
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1051" alias="sa977">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1205" alias="csa43">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00740" species="s837">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa978</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00741" species="s1051">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa977</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00742" species="s1205">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re286" id="re286" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04620+23643
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s235" alias="sa979">
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</celldesigner:baseReactant>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1204" alias="csa44">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
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</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1056" alias="sa976">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00743" species="s235">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa979</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00744" species="s328">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa980</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00745" species="s1204">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00746" species="s1205">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re287" id="re287" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s600" alias="sa981">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s894" alias="sa982">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1213" alias="csa45">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00747" species="s600">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa981</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00748" species="s894">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa982</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00749" species="s1213">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re288" id="re288" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s192" alias="sa147">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1067" alias="sa984">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.035136474296771025,-0.02070387947548491 0.22258649294026966,-0.45808453679308503</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00750" species="s192">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa147</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00751" species="s1067">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa984</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re289" id="re289" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04650+3383
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s886" alias="sa849">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1210" alias="csa46">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1211" alias="csa32">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s1067" alias="sa984" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="S"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.457491901300628,0.3298144954631095</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00752" species="s886">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa849</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00753" species="s1210">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa46</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00754" species="s1067">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa984</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00755" species="s1211">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re290" id="re290" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+2335
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1074" alias="sa989">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1075" alias="sa990">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1212" alias="csa47">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.4130522357996451,0.33543708876058176</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00756" species="s1074">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa989</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00757" species="s1075">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa990</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00758" species="s1212">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re291" id="re291" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+4233
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1077" alias="sa991">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1078" alias="sa992">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1214" alias="csa48">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.34928351446969685,0.3132937972460681</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00759" species="s1077">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa991</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00760" species="s1078">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa992</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00761" species="s1214">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re292" id="re292" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+1950
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1080" alias="sa993">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1081" alias="sa994">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1216" alias="csa49">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00762" species="s1080">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa993</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00763" species="s1081">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa994</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00764" species="s1216">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re293" id="re293" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+7124
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactant>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1217" alias="csa50">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00765" species="s734">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa297</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00766" species="s1001">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa996</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00767" species="s1217">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re294" id="re294" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04010+7040
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s464" alias="sa746">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1090" alias="sa998">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1215" alias="csa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00768" species="s464">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa746</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00769" species="s1090">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa998</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00770" species="s1215">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re295" id="re295" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1096" alias="sa1001">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s857" alias="sa786">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1185" alias="csa53">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.42640377975650345,0.35462475013629025</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00771" species="s1096">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1001</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00772" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00773" species="s1185">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re296" id="re296" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04520+60
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1097" alias="sa1002">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1097" alias="sa1003">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s335" aliases="sa421" targetLineIndex="-1,5" editPoints="0.007122883946279579,-0.046238570262302936 0.9839426725557789,0.10423697323361525">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s335" alias="sa421">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s956" aliases="sa917" targetLineIndex="-1,2" editPoints="0.5870196068923255,-0.2681658566811116 0.7596776448223919,0.10978551567809092">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s956" alias="sa917">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s930" aliases="sa891" targetLineIndex="-1,3" editPoints="0.9834891281463053,0.12742944308253656">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s930" alias="sa891">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s1106" aliases="sa1010" targetLineIndex="-1,6" editPoints="0.008582950357398644,0.06697466686448683 0.9924253225477959,-0.059106889570898546">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1106" alias="sa1010">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00774" species="s1097">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1002</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00775" species="s1097">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1003</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00776" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa421</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00777" species="s956">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa917</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00778" species="s930">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa891</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00779" species="s1106">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1010</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re297" id="re297" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04810+2909
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1098" alias="sa1004">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1100" alias="sa1005">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s861" aliases="sa824" targetLineIndex="-1,2" editPoints="0.9607076518062677,-0.19428962804832048">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s861" alias="sa824">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00780" species="s1098">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1004</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00781" species="s1100">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1005</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00782" species="s861">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa824</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re298" id="re298" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+4193
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1102" alias="sa1007">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1103" alias="sa1008">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s711" aliases="sa695" targetLineIndex="-1,2" editPoints="0.31530373477373796,-0.04289471789084631 0.333474998880122,0.09067574765884023">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s711" alias="sa695">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00783" species="s1102">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1007</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00784" species="s1103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1008</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00785" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re299" id="re299" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+4193
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1101" alias="sa1009">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1105" alias="sa1006">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s711" aliases="sa695" targetLineIndex="-1,2" editPoints="0.6999675093507864,0.14725627167912592 0.742349760865606,-0.05420339245082495">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s711" alias="sa695">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1241" aliases="sa313" targetLineIndex="-1,3" editPoints="0.010716277666213192,0.03009664275862517 0.8982007244078405,-0.2859030463762458">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00786" species="s1101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1009</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00787" species="s1105">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1006</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00788" species="s711">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa695</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00789" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re300" id="re300" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1103" alias="sa1008">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1101" alias="sa1009">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.930270163499181,-0.024071364281140095 0.9309392658283675,0.0017869928059557338</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00790" species="s1103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1008</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00791" species="s1101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1009</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re301" id="re301" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04910+5139
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1107" alias="sa1012">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1108" alias="sa1013">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1241" aliases="sa313" targetLineIndex="-1,3" editPoints="0.01299749443928469,-0.06290756941247788 0.972056462925154,0.1352460665690241">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00792" species="s1107">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1012</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00793" species="s1108">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1013</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00794" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re302" id="re302" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?ko04020+C00575
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s954" alias="sa1014">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1109" alias="sa914">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s466" aliases="sa318" targetLineIndex="-1,2" editPoints="0.23885589281407638,0.017214721187074566 0.24402336375776368,-0.05448442934996667">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s466" alias="sa318">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1108" aliases="sa1013" targetLineIndex="-1,4" editPoints="0.08250900827104957,-0.1730816120939913 0.8973399620509768,0.21535302918047217">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1108" alias="sa1013">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00795" species="s954">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1014</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00796" species="s1109">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa914</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00797" species="s466">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa318</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00798" species="s1108">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1013</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re303" id="re303" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+2889
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1110" alias="sa1015">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1110" alias="sa1016">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s857" aliases="sa786" targetLineIndex="-1,2" editPoints="0.19095691112078583,-0.32291512847042014 0.9318630287781673,0.11522211312774466">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s857" alias="sa786">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00799" species="s1110">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1015</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00800" species="s1110">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1016</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00801" species="s857">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa786</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re304" id="re304" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+2889
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1114" alias="sa1019">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1114" alias="sa1020">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s745" aliases="sa708" targetLineIndex="-1,2" editPoints="0.19986272129418503,0.0663266958026556 0.29906886080467365,-0.23261189553997141">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s745" alias="sa708">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s1255" aliases="sa1105" targetLineIndex="-1,2" editPoints="-7.264819946417589E-5,0.0052328814128325685 0.9997346506856715,0.019113226550646845">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1255" alias="sa1105">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00802" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1019</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00803" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1020</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00804" species="s1206">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00107" species="s1254">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re305" id="re305" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+2773
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1289" alias="sa1021">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1289" alias="sa913">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1114" aliases="sa1020" targetLineIndex="-1,3" editPoints="0.08070826087704219,0.08745944033544895 0.6207891818505669,-0.41093149033435594">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1114" alias="sa1020">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00805" species="s1289">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1021</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00806" species="s1289">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa913</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00807" species="s1114">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1020</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re306" id="re306" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+3479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1120" alias="sa1025">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1117" alias="sa1024">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1200" alias="csa55">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.3256835937500021,0.3155924479166643</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00808" species="s1120">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1025</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00809" species="s1117">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1024</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00810" species="s1200">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re307" id="re307" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04670+3702
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1121" alias="sa1026">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1121" alias="sa1027">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s862" aliases="sa311" targetLineIndex="-1,2" editPoints="0.3240340933033191,-0.4680128199957934">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s862" alias="sa311">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00811" species="s1121">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1026</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00812" species="s1121">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1027</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00813" species="s862">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa311</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re308" id="re308" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04660+1437
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1122" alias="sa1028">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1123" alias="sa1029">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s921" aliases="sa882" targetLineIndex="-1,5" editPoints="0.0799078830317912,-0.030449370702230638 0.2067007105512222,0.30229137884470836">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s921" alias="sa882">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s325" aliases="sa274" targetLineIndex="-1,2" editPoints="0.020607923776193887,-0.005105485301544643 0.07843562305240323,0.22831185868263626">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s325" alias="sa274">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s5" aliases="sa3" targetLineIndex="-1,4" editPoints="-0.21215398869731494,-0.20430586398831657 0.26900784825961566,-0.7039508615747656">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s5" alias="sa3">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00814" species="s1122">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1028</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00815" species="s1123">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1029</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00816" species="s921">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa882</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00817" species="s325">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa274</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00818" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re309" id="re309" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04010+3925
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1124" alias="sa1030">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1125" alias="sa1031">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s324" aliases="sa272" targetLineIndex="-1,2" editPoints="0.22409820233848876,-0.009937844655972583 0.226060904648703,0.03432105399564733">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s324" alias="sa272">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00819" species="s1124">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1030</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00820" species="s1125">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1031</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00821" species="s324">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa272</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re310" id="re310" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04670+653361
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1188" alias="csa56">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1188" alias="csa57">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s764" aliases="sa368" targetLineIndex="-1,3" editPoints="0.8879271190261436,-0.31545609888552795">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s764" alias="sa368">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s1133" aliases="sa1043" targetLineIndex="-1,4">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1133" alias="sa1043">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00822" species="s1188">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa56</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00823" species="s1188">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00824" species="s764">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa368</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00825" species="s1133">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1043</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re311" id="re311" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04670+4689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1135" alias="sa1045">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1136" alias="sa1046">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1188" aliases="csa57" targetLineIndex="-1,2" editPoints="0.33661272823259925,-0.4280791651656308 0.9545377119085847,0.05781557469581067">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1188" alias="csa57">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00826" species="s1135">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1045</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00827" species="s1136">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1046</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00828" species="s1188">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re312" id="re312" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04670+4689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s168" alias="sa127">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s168" alias="sa372">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1136" aliases="sa1046" targetLineIndex="-1,3" editPoints="3.77436927131658E-4,-0.04768683344121194 1.0003147950735578,-0.03977242066628739">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1136" alias="sa1046">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00829" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa127</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00830" species="s168">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa372</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00831" species="s1136">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1046</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re313" id="re313" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04620+8772
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s131" alias="sa95">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1137" alias="sa1047">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00832" species="s131">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa95</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00833" species="s1137">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1047</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re314" id="re314" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>PMID: 18205922
http://www.ncbi.nlm.nih.gov/pubmed/18205922
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1201" alias="csa40">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1137" alias="sa1047">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.008565999146411374,0.0790591332983491 0.996962653689121,-0.028032919775112762</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00834" species="s1201">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00835" species="s1137">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1047</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re315" id="re315" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04115+3479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s997" alias="sa943">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1137" alias="sa1047">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7269135665328891,-0.19847364045887383 0.7962903269650956,0.05562009331696105</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00836" species="s997">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa943</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00837" species="s1137">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1047</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re319" id="re319" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1143" alias="sa1053">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1142" alias="sa1052">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1144" alias="csa58">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.2702597582997619,0.4523683844978468</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00843" species="s1143">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1053</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00844" species="s1142">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1052</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00845" species="s1144">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re320" id="re320" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04012+572
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1143" alias="sa1053">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1148" alias="sa1056">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1241" aliases="sa313" targetLineIndex="-1,2" editPoints="0.15997899856991937,0.3665865772044649">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1241" alias="sa313">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00847" species="s1143">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1053</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00848" species="s1148">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1056</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00849" species="s1241">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa313</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re321" id="re321" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg/pathway.html
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1151" alias="sa1057">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1152" alias="sa1058">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1153" alias="csa59">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.3253626909744476,0.31778790602131224</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00850" species="s1151">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1057</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00851" species="s1152">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1058</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00852" species="s1153">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re323" id="re323" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04260+7134
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1261" alias="sa1064">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1261" alias="sa1065">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1133" aliases="sa1043" targetLineIndex="-1,6">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1133" alias="sa1043">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1157" aliases="sa1062" targetLineIndex="-1,3" editPoints="0.576396299705948,-0.4941291383750226">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1157" alias="sa1062">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1158" aliases="sa1063" targetLineIndex="-1,7" editPoints="-0.19583569031198245,-0.23910783737616015 0.40267832562831885,-0.7293067650201479">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1158" alias="sa1063">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00855" species="s1261">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1064</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00856" species="s1261">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1065</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00857" species="s1133">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1043</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00858" species="s1157">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1062</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00859" species="s1158">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1063</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re324" id="re324" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04260+7137
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1161" alias="sa1066">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1163" alias="sa1068">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1164" alias="csa60">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s1162" alias="sa1067" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="E"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.41411207435874364,0.3652694610778511</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00860" species="s1161">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1066</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00861" species="s1163">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1068</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00862" species="s1162">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1067</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00863" species="s1164">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re325" id="re325" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG 
http://www.genome.jp/kegg-bin/show_pathway?hsa04260+7134
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1167" alias="sa1071">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1169" alias="sa1072">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s1133" alias="sa1043" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="S"/>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00864" species="s1164">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00865" species="s1133">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1043</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00866" species="s1169">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1072</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re327" id="re327" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04260+70
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1174" alias="sa1076">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1161" alias="sa1066">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1175" alias="csa62">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.2580896481325823,0.3308837216284317</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00867" species="s1174">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1076</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00868" species="s1161">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1066</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00869" species="s1175">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re328" id="re328" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1179" alias="sa1080">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1180" alias="sa1081">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00870" species="s1179">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1080</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00871" species="s1180">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1081</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re329" id="re329" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04310+51701
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1180" alias="sa1081">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1181" alias="sa1082">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00872" species="s1180">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1081</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00873" species="s1181">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1082</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re330" id="re330" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04260+70
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1171" alias="csa61">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1173" alias="sa1075">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
<celldesigner:baseProduct species="s1162" alias="sa1067">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.49006821829856406,0.1968298555377217</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00874" species="s1171">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa61</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00875" species="s1173">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1075</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00876" species="s1162">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1067</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re331" id="re331" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479 PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s335" alias="sa421">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s400" alias="sa324">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00877" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa421</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00878" species="s400">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa324</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re332" id="re332" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/19290479
PMID: 19290479
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:linkAnchor position="SW"/>
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<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00879" species="s335">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa421</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00880" species="s401">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa325</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re333" id="re333" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>PMID: 19342689 
http://www.ncbi.nlm.nih.gov/pubmed/19342689
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s350" alias="sa289">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00881" species="s1247">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1086</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00882" species="s1248">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1087</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00883" species="s350">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa289</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re334" id="re334" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1245" alias="sa160">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s266" alias="sa223">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:editPoints>0.03544779034058232,-0.18490874641442037</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00884" species="s1245">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa160</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00885" species="s266">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa223</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re335" id="re335" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+6772
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1249" alias="sa1097">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1250" alias="sa1098">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s794" aliases="sa759" targetLineIndex="-1,2" editPoints="0.34034095915777174,0.2939171036044963 0.7675370414532086,-0.2007540897824518">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s794" alias="sa759">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00488" species="s1249">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1097</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00489" species="s1250">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1098</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00886" species="s794">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa759</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re336" id="re336" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>http://www.ncbi.nlm.nih.gov/pubmed/18629129
PMID: 18629129
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s121" alias="sa86">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1251" alias="sa1099">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s732" aliases="sa183" targetLineIndex="-1,2" editPoints="0.635401332619282,-0.48131744111856545">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s732" alias="sa183">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00205" species="s119">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00206" species="s1251">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1099</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00207" species="s732">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa183</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re337" id="re337" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+595
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s184" alias="sa139">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1252" alias="sa1100">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s5" aliases="sa3" targetLineIndex="-1,2" editPoints="0.36996288142490574,-0.3689701683525186 0.8686194426911716,0.1310280268165922">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s5" alias="sa3">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00887" species="s184">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa139</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00888" species="s1252">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1100</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00889" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re338" id="re338" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+7852
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1258" alias="sa1102">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1259" alias="sa1103">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1254" alias="csa63">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.004360441568053375,0.31742701534008155</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00108" species="s1258">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1102</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00838" species="s1259">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1103</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00839" species="s1254">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re339" id="re339" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04062+7852
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1258" alias="sa1102">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1255" alias="sa1105">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s746" aliases="sa709" targetLineIndex="-1,3" editPoints="0.02860670054894232,0.16669840200987313">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s746" alias="sa709">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00840" species="s1258">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1102</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00841" species="s1254">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00842" species="s746">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa709</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re340" id="re340" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+971
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1262" alias="sa1106">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1266" alias="sa1108">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1265" alias="csa64">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.37761407673777225,0.3266068498411485</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00846" species="s1262">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1106</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00853" species="s1266">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1108</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00854" species="s1265">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re341" id="re341" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04621+64127
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1267" alias="sa1109">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1267" alias="sa1110">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s1268" aliases="sa1111" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1268" alias="sa1111">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00890" species="s1267">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1109</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00891" species="s1267">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1110</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00892" species="s1268">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1111</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re342" id="re342" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04621+64127
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s326" alias="sa275">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s327" alias="sa276">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s1267" aliases="sa1110" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1267" alias="sa1110">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00893" species="s326">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa275</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00894" species="s104">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00895" species="s1267">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1110</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re344" id="re343" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa05200+3728
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1278" alias="sa1112">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1279" alias="sa1113">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s1269" aliases="sa136" targetLineIndex="-1,2" editPoints="0.12634747315620132,0.006615189488586637 0.1290812468956437,-0.04559879542526257">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1269" alias="sa136">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00901" species="s1278">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1112</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00902" species="s1279">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1113</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00903" species="s1269">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa136</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="CDMT00896" id="re344" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04510+29780
</body>
</html>
</notes>
<annotation>
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<celldesigner:extension>
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</reaction>
<reaction metaid="re345" id="re345" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+118788
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
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</reaction>
<reaction metaid="re346" id="re346" reversible="false">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>KEGG
http://www.genome.jp/kegg-bin/show_pathway?hsa04662+29760
</body>
</html>
</notes>
<annotation>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</annotation>
</speciesReference>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

