Welcome to dbDEMC
dbDEMC (database of Differentially Expressed MiRNAs in human Cancers) is an integrated database
that designed to store and display differentially expressed microRNAs (miRNAs) in cancers detected
by high-throughput and low-throughput methods. In this updated version, dbDEMC extend the cancer
related miRNA data to other model organisms including mouse and rat, we collected a total of 403
miRNA expression data sets, which based on platforms of microarray or miRNA-seq, from public
repositories including Gene Expression Omnibus (GEO), Sequence Read Archive (SRA), ArrayExpress
and The Cancer Genome Atlas (TCGA). The differentially expressed miRNAs were then identified and
displayed for 9 different types of experiments. This current version contains 3,268 differentially
expressed miRNAs from 40 cancer types, whereas for human, a total of 2,584 differentially expressed
miRNA were included. For each differentially expressed miRNA set, we also collected the experimentally
validated targets from public databases and constructed the miRNA regulatory network. A gene set
enrichment analysis was used to investigate the functions of the differentially expressed miRNAs.
Enhanced web page for visualization of the data and also several other improved or novel features
were provided in the database for much easier to use. dbDEMC will continue to play an important
role in cancer research.
Citation
[1]
Feng Xu#, Yifan Wang#, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E Teschendorff, Yi Zhao, Haitao Zhao, Yungang He*, Guoqing Zhang*, Zhen Yang*. dbDEMC 3.0: Functional exploration of differentially expressed miRNAs in cancers of human and model organisms. Genomics, Proteomics & Bioinformatics. 2022, 20(3):446-454.
[
doi: 10.1016/j.gpb.2022.04.0062022
]