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We study how proteins and other biomacromolecules
function by investigating their mechanics, dynamics and evolution.
Proteins and RNA are constantly perturbed by their
environment by external stimuli such as binding partners, by mechanical
force, and by changes in pH, temperature and other factors.
These perturbations are the basic elements of the
information curcuits in the cell. Examples are allosteric enzymes,
modifications of natively unfolded proteins, or proteins under
mechanical stress.
Our group uses molecular simulations, mainly
atomic-detail Molecular Dynamics simulations, in combination with
evolutionary analyses to decipher how proteins are regulated by and
function upon perturbations.
We aim at explaining and predicting the molecular
basis of communication in cells, in signalling cascades and throughout
larger protein assemblies, to investigate how it might be modified for
new purposes.
People:
Former members:
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