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> Research My work as a Ph. D. student was dedicated to the structural properties of peptides, especially peptides built from non-proteinogenic amino acids. The work was supported by the DFG as Project HO 2346/1 'Sekundärstrukturbildung in Peptiden mit nicht-proteinogenen Aminosäuren' and within SFB-610. I performed theoretical conformational analyses on several classes of foldamers (α-, β-, γ- and δ-peptides, vinylogous γ-peptides, sulfonamidopeptides) applying ab initio and force field methods. Afterwards, in the group of M. Teresa Pisabarro at the Biotec in Dresden, my fields of interest grew into protein-protein and protein-peptide interactions and their imitation and inhibition with mimetic scaffolds based on known foldamers. I am grateful for funding to the Free State of Saxony and to Klaus Tschira Foundation. Currently, my research deals with the molecular and atomic basis of the function and activity of von Willebrand factor (VWF). The investigations cover the influence of shear flow and several protein-protein interactions related to blood clotting. The work is supported by Alexander-von-Humboldt Foundation. Recently also the development and application of novel algorithms to the problem of molecular docking came into the focus of my interest. Therefore I am in close contact with colleagues from Halle, Odense, and Leipzig. Together we develop the Parallel Docking Suite (ParaDocks). > Workshops and Conferences SHEAR-2009 META-2008 MDCO-2007
> Publications Publications in Reviewed Journals: Baldauf, C.; Schneppenheim, R.; Stacklies W.;
Obser, T.; Pieconka A.; Schneppenheim S.; Budde U.; Gräter F.; Shear-Induced Unfolding Activates von
Willebrand Factor A2 Domain for Proteolysis. Journal of Thrombosis and Haemostasis,
ACCEPTED Baldauf, C.; Pisabarro, M. T.; Stable Hairpins
with β-Peptides - A
Route to Tackle Protein-Protein Interactions J.
Phys. Chem. B 2008 (112), 7581-7591. Scheike, J. A.; Baldauf, C.; Spengler, J.;
Albericio, F.;
Pisabarro, M. T.; Koksch, B.; Amide-to-Ester Substitution in Coiled
Coils: The Effect of Removing Hydrogen Bonds on Protein Structure Angew.
Chem. 2007 (119), 7912-7916. Angew.
Chem. Int. Ed. 2007 (46), 7766-7769. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Theoretical
Prediction of the Basic Helix Types in Helices
α,β-Hybrid Peptides Biopolymers:
Peptide Science 2006 (84), 408-413. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Helices
in Peptoids of α- and β-Peptides Phys. Bio. 2006
(3), S1-S9. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Helix
Formation in α,γ- and β,γ-Hybrid Peptides - Theoretical
Insights into Mimicry of α- and β-Peptides J.
Org. Chem. 2006 (71), 1200-1208. Lang, M.; De Pol, S.; Baldauf, C.; Hofmann, H.-J.;
Reiser,
O.; Beck-Sickinger, A. G.; Identification of the Key Residue of
Calcitonin Gene Related
Peptide (CGRP) 27-37 to Obtain Antagonists with Picomolar Affinity at
the CGRP Receptor J.
Med. Chem. 2006 (49), 616-624. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Side
Chain Control of Folding of the Homologous α-, β- and
γ-Peptides into "Mixed" Helices (β-Helices) Biopolymers:
Peptide Science 2005 (80), 675-687. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Control
of Helix Formation in Vinylogous γ-Peptides by (E)-
and (Z)-
Double Bonds - A Way to Ion Channels and Monomolecular Nanotubes J.
Org. Chem. 2005 (70), 5351-5361. Baldauf, C.; Günther, R.; Hofmann, H.-J.; δ-Peptides
and δ-Amino Acids as Tools for Peptide Structure
Design - A Theoretical Study J.
Org. Chem. 2004 (69), 6214-6220. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Conformational
properties of sulfonamido peptides J. Mol.
Struct. (Theochem) 2004 (675), 19-28. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Mixed
Helices - A General Folding Pattern in Homologous
Peptides? Angew.
Chem. 2004 (116), 1621-1624. Angew.
Chem. Int. Ed. 2004 (43), 1594-1597.
Oral Presentations: Baldauf, C.; Pisabarro, M. T.; Imitating β-Hairpins with More Robust β-Peptide Folds 2nd International Symposium on Biomolecules and Related Compounds, Kyoto, Japan, November 10th-12th, 2006. Baldauf, C.; Scheike, J. A.; Spengler, J.; Albericio, F.; Koksch, B.; Pisabarro, M. T.; Amide to Ester Substitutions in Coiled Coils - The Effect of H-Bond Elimination on Protein Structure Formation 20th American Peptide Symposium, Montreal, QC, Canada, June 26th-30th, 2007. Proceedings: Baldauf, C.; Günther, R.; Hofmann, H.-J.; Vinylogous γ-Amino Acids as Building Blocks for Foldamers, In: Peptides - Peptide Revolution: Genomics, Proteomics & Therapeutics. Proc. of the 18th American Peptide Symposium; Eds. Chorev, M.; Sawyer, T. K.; American Peptide Society: San Diego, 2004; pp 441-442. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Helix Formation in Oligomers of γ-Amino Acids, In: Peptides - Peptide Revolution: Genomics, Proteomics & Therapeutics. Proc. of the 18th American Peptide Symposium; Eds. Chorev, M.; Sawyer, T. K.; American Peptide Society: San Diego, 2004; pp 439-440. Baldauf, C.; Günther, R.; Hofmann, H.-J.; Helix Formation in α/β, α/γ- and β/γ-Hybrid Peptides, In: Understanding Biology Using Peptides. Proc. of the 19th American Peptide Symposium; Ed. Blondelle, S.; American Peptide Society: San Diego, 2006; pp 671-672. Baldauf, C.; Pisabarro, M. T.; Imitating β-Hairpins with More Robust β-Peptide Folds, In: Peptide Science 2006. Proc. of the 43rd Japanese Peptide Symposium and the 4th Peptide Engineering Meeting; Eds. Ishida, H.; Mihara, H.; The Japanese Peptide Society: Osaka, 2006; p 143.
Poster Presentations: Baldauf, C.; Günther, R.; Hofmann, H.-J.; Konformation und Faltung in Sulfonamidopeptiden 16. CIC Workshop, Kleinmachnow/Berlin, November 10th-12th, 2002. pdf
Diplomarbeit (Diploma thesis): Sulfonamidopeptide und vinyloge Peptide als Foldamere Universität Leipzig 2002. pdf[1442k] Doktorarbeit (Ph.D. thesis): Secondary Structure Formation in Homologous Peptides Universität Leipzig 2005. pdf[3663k] > Curriculum Vitae
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