Dr. Scott Edwards Scientific Coordinator & Senior Scientist Partner Institute for Computational Biology (PICB) Chinese Academy of Sciences Max-Planck Society E-Mail : edwardsscott@picb.ac.cn

> Research

I work on the application of analytical, numerical and simulation methods to problems in soft matter physics. I particularly enjoy problems that are relevant to or inspired by biology. My current focus is on studying force propagation through proteins and other biological materials. I am especially interested in understanding pre-stress in protein force networks - to what extent it influences the mechanical properties and allosteric response of proteins, and how it can be engineered via well-chosen mutations.


>Bioinformatics and Algorithms course, 2011
    Protein Structure and Function

• Lecture1
• Lecture2
  
• Lecture3
• Lecture4

> Publications

Dynamic Pre-stress in a Globular Protein
S. A. Edwards, J. Wagner and F. Graeter
In preparation

A New Transferable Forcefield for Simulating the Mechanical Properties of CaCO3
S. J. Xiao, S. A. Edwards and F. Graeter
Accepted to J Phys Chem C (2011)
DOI: 10.1021/jp202743v

Glycosylation Enhances Peptide Hydrophobic Collapse by Impairing Solvation
S. M. Cheng, S. A. Edwards, Y. D. Jiang and F. Graeter
ChemPhysChem 11, 2367 (2010)
DOI: 10.1002/cphc.201000205

Effects of Internal Flow and Viscosity Ratio on Measurements of Dynamic Forces between Deformable Drops
S. A. Edwards, S. L. Carnie, O. Manor and D. Y. C. Chan
Langmuir 25, 3352 (2009)
DOI: 10.1021/la8042473

Spontaneous Flow States in Active Nematics: A Unified Picture
S. A. Edwards and J. M. Yeomans
Euophysics Letters 85, 18008 (2009)
DOI: 10.1209/0295-5075/85/18008

Influence of Atomic Force Microscope Cantilever Tilt and Induced Torque on Force Measurements
S. A. Edwards, W. A. Ducker and J. E. Sader
Journal of Applied Physics 103, 064518 (2008)
DOI: 10.1063/1.2885734

Measurements of Dynamic Forces between Drops with the AFM: Novel Considerations in Comparisons between Experiment and Theory
G. B. Webber, S. A. Edwards, S. L. Carnie, G. W. Stevens, F. G. Grieser, R. R. Dagastine and D. Y. C. Chan
Soft Matter 4, 1270 (2008)
DOI: 10.1039/b717303b

Dynamic Forces between a Moving Particle and a Deformable Drop
G. B. Webber, R. Manica, S. A. Edwards, S. L. Carnie, G. W. Stevens, F. G. Grieser, R. R. Dagastine and D. W. C. Chan
Journal of Physical Chemistry C 112, 567 (2008)
DOI: 10.1021/jp076215d

Atomic force microscopy: Loading position dependence of cantilever spring constants and detector sensitivity
I. U. Vakarelski, S. A. Edwards and R. R. Dagastine
Review of Scientific Instruments 78, 116102 (2007)
DOI: 10.1063/1.2805518

Surface Tension of Electrolyte Solutions: Comparing the Effects of Ionic Dispersion Forces and Solvation
S. A. Edwards and D. R. M. Williams
Europhysics Letters 74, 854 (2006)
DOI: 10.1209/epl/i2006-10030-0

Stretching a Single Diblock Copolymer in a Selective Solvent – Langevin Dynamics Simulations
S. A. Edwards and D. R. M. Williams
Macromolecules 38, 10590 (2005)
DOI: 10.1021/ma0500483

Hofmeister Effects in Colloid Science and Biology Explained by Dispersion Forces: Analytic Results for the Double Layer Interaction
S. A. Edwards and D. R. M. Williams
Current Opinion in Colloid & Interface Science 9(1-2), 139 (2004)
DOI: 10.1016/j.cocis.2004.05.019

Double Layers and Interparticle Forces in Colloid Science and Biology: Analytic Results for the Effect of Ionic Dispersion Forces
S. A. Edwards and D. R. M. Williams
Physical Review Letters 92, 248303 (2004)
DOI: 10.1103/PhysRevLett.92.248303

Substructure in the Coma Cluster: Giants versus Dwarfs
S. A. Edwards , M. Colless, T. J. Bridges, D. Carter, B. Mobasher and B. M. Poggianti
Astrophysical Journal 567, 178 (2002)
DOI: 10.1086/338495

Continuum Electrostatics Fails to Describe Ion Permeation in the Gramicidin Channel
S. Edwards , B. Corry, S. Kuyucak and S-H Chung
Biophysical Journal 83, 1348 (2002)
DOI: 10.1016/S0006-3495(02)73905-2

> Curriculum Vitae

2007 – 2008 Postdoc in the group of Prof Julia Yeomans
Department of Theoretical Physics, University of Oxford

2006 – 2007 Postdoc in the group of Prof Derek Chan
Particulate Fluids Processing Centre, University of Melbourne

2002 – 2005 PhD student in the group of Prof David Williams
Australian National University

2001 – 2002 Certificate of Advanced Studies, Cambridge University, UK

1997 – 2000 BSc (Hons), Australian National University



> Outside Interests

• Music (guitar)
• Learning Chinese