Wang SiJia Principal Investigator Email:wangsijiapicb.ac.cn Address: 320 Yue Yang Road,Shanghai,China ZipCode: 200031
Research Interests:
Dermatogenomics Human phenome research
Resume:
Sijia WANG published over 30 papers in famous international scientific journals like Cell, PLoS Genet, J Invest Dermatol, etc. He has more than 2,000 citations. He was invited to be the referee of more than 10 internationally renowned magazines such as Cell, Nat Genet, Elife, Curr Biol, PLoS Genet, Genome Res. He was also invited as senior associate editor of Ann Hum Genet.
Education and Research Training:
B.Sc. in Biosciences (1998-2002): Fudan University, Shanghai, China M.Sc. in Biological Anthropology (2002-2003): Durham University, Durham, UK Ph.D. in Human Genetics (2003-2008): University College London, London, UK Postdoctoral Fellow (2009-2012): Harvard University, Cambridge, MA, USA; Affiliated Research Fellow (2009-2012): The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Recent Publications:
Yimei Tan#, Fudi Wang#, Guobiao Fan#, Yan Zheng, Bingjie Li, Ning Li, Yu Liu, Xuemin Wang, Wei Liu, Jean Krutmann*, Ying Zou, Sijia Wang*, Identification of factors associated with minimal erythema dose variations in a large-scale population study of 22 146 subjects. J Eur Acad Dermatol Venereol, 2020 Jan 19. Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L Marazita, John R Shaffer, Kerrie McAloney, Shu-Hua Xu, Li Jin, Sijia Wang, Femke MS de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei Zhurov, Sarah Lewis, Gemma C Sharp, Lavinia Paternoster, Holly Thompson, Rolando Gonzalez-Jose, Maria Catira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, Andre G Uitterlinden, M Arfan Ikram, Eppo Wolvius, Steven A Kushner, Tamar EC Nijsten, Robert-Jan TS Palstra, Stefan Boehringer, Sarah E Medland, Kun Tang, Andres Ruiz-Linares, Nicholas G Martin, Timothy D Spector, Evie Stergiakouli, Seth M Weinberg, Fan Liu*, Manfred Kayser*, on behalf of the International Visible Trait Genetics (VisiGen) Consortium, Novel genetic loci affecting facial shape variation in humans. Elife, 2019 Nov 26;8. pii: e49898. Yu Liu#, Wenshan Gao#, Claudia Koellmann, Sigrid Le Clerc, Anke Huls, Bingjie Li, Qianqian Peng, Sijie Wu, Anan Ding, Yajun Yang, Li Jin, Jean Krutmann, Tamara Schikowski*, Jean-Francois Zagury*, Sijia Wang*, Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci, 2019 Oct;96(1):42-49. Ewelina Pospiech, Yan Chen, Magdalena Kukla-Bartoszek, Krystal Breslin, Anastasia Aliferi, Jeppe D. Andersen, David Ballard, Lakshmi Chaitanya, Ana Freire-Aradas, Kristiaan J. van der Gaag, Lorena Giron-Santamaria, Theresa E. Gross, Mario Gysi, Gabriela Huber, Ana Mosquera-Miguel, Charanya Muralidharan, Malgorzata Skowron, Angel Carracedo, Cordula Haas, Niels Morling, Walther Parson, Christopher Phillips, Peter M. Schneider, Titia Sijen, Denise Syndercombe-Court, Marielle Vennemann, Sijie Wu, Shuhua Xu, Li Jin, Sijia Wang, Ghu Zhu, Nick G. Martin, Sarah E. Medland, Wojciech Branicki, Susan Walsh, Fan Liu, Manfred Kayser*, Towards broadening Forensic DNA Phenotyping beyond pigmentation: Improving the prediction of head hair shape from DNA. Forensic Sci Int Genet, 2018 Nov;37:241-251. Sijie Wu#, Manfei Zhang#, Xinzhou Yang#, Fuduan Peng, Juan Zhang, Jingze Tan, Yajun Yang, Lina Wang, Yanan Hu, Qianqian Peng, Jinxi Li, Yu Liu, Yaqun Guan, Chen Chen, Merel A. Hamer, Tamar Nijsten, Changqing Zeng, Kaustubh Adhikari, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Hui Li, Jean Krutmann, Fan Liu, Manfred Kayser, Andres Ruiz-Linares, Kun Tang, Shuhua Xu, Liang Zhang*, Li Jin*, Sijia Wang*, Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet, 2018 Sep 24;14(9):e1007640. Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Shouneng Peng, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Li Jin, Yaqun Guan,Sijia Wang*, Shuhua Xu*, Kun Tang*, Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction. J Genet Genomics, 2018 Aug 20;45(8):419-432. Fan Liu*#, Yan Chen#, Gu Zhu, Pirro G Hysi, Sijie Wu, Kaustubh Adhikari, Krystal Breslin, Ewelina Pospiech, Merel A Hamer, Fuduan Peng Charanya Muralidharan, Victor Acuna-Alonzo, Samuel Canizales-Quinteros, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Francisco Rothhammer, Maria Catira Bortolini, Rolando Gonzalez-Jose, Changqing Zeng, Shuhua Xu, Li Jin, Andre G Uitterlinden, M Arfan Ikram, Cornelia M van Duijn, Tamar Nijsten, Susan Walsh, Wojciech Branicki, Sijia Wang, Andres Ruiz-Linares, Timothy D Spector, Nicholas G Martin, Sarah E Medland*, Manfred Kayser*, Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair. Hum Mol Genet, 2018 Feb 1;27(3):559-575. Jing Li#, Ruiqing Fu#, Yajun Yang, Hans-Peter Horz, Yaqun Guan, Yan Lu, Haiyi Lou, Lei Tian, Shijie Zheng, Hongjiao Liu, Meng Shi, Kun Tang, Sijia Wang*, Shuhua Xu*, A metagenomic approach to dissect the genetic composition of enterotypes in Han Chinese and two Muslim groups. Syst Appl Microbiol, 2018 Jan;41(1):1-12. John R. Shaffer#, Jinxi Li#, Myoung Keun Lee, Jasmien Roosenboom, Ekaterina Orlova, Kaustabh Adhikari, 23andMe Research Team, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Paige E. Pfeffer, Christopher A. Wollenschlaeger, Jacqueline T. Hecht, George L. Wehby, Lina M. Moreno, Anan Ding, Li Jin, Yajun Yang, Jenna C. Carlson, Elizabeth J. Leslie, Eleanor Feingold, Mary L. Marazita, David A. Hinds, Timothy C. Cox, Sijia Wang*, Andres Ruiz-Linares, and Seth M. Weinberg*, Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment. Am J Hum Genet, 2017 Dec 7;101(6):913-924. Anan Ding#, Yajun Yang#, Zhuohui Zhao#, Anke Huls, Andrea Vierkotter, Ziyu Yuan, Jing Cai, Juan Zhang, Wenshan Gao, Jinxi Li, Manfei Zhang, Mary Matsui, Jean Krutmann, Haidong Kan, Tamara Schikowski*, Li Jin*, Sijia Wang*, Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep, 2017 Nov 10;7(1):15329. Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*, Genetic history of Xinjiang's Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Mol Biol Evol, 2017 Oct 1;34(10):2572-2582. Wenshan Gao#, Jingze Tan#, Anke Huls#, Anan Ding, Yu Liu, Mary S. Matsui, Andrea Vierkotter, Jean Krutmann, Tamara Schikowski*, Li Jin*, Sijia Wang*, Genetic variants associated with skin aging in the Chinese Han population. J Dermatol Sci, 2017 Apr;86(1):21-29. Manfei Zhang#, Bingjie Li#, Sijie Wu, Jingze Tan, Yajun Yang, Alessandra Marini, Andrea Vierkotter, Juan Zhang, Hui Li, Tamara Schikowski, Li Jin, Jean Krutmann, Sijia Wang*, A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol, 2017 Apr;137(4):979-982. Manfei Zhang#, Sijie Wu#, Juan Zhang#, Yajun Yang#, Jingze Tan, Yu Liu, Haijuan Guan, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan*, Hui Li*, Sijia Wang*, Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics, 2016 Dec 20;43(12):702-704. Sijie Wu#, Jingze Tan#, Yajun Yan#, Qianqian Peng, Manfei Zhang, Jinxi Li, Dongsheng Lu, Yu Liu, Haiyi Lou, Qidi Feng, Yan Lu, Yanqun Guan, Zhaoxia Zhang, Yi Jiao, Pardis Sabeti, Jean Krutmann, Kun Tang, Li Jin*, Shuhua Xu*, Sijia Wang*, Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet, 2016 Nov;135(11):1279-1286. Andrea Vierkotter#, Anke Huls#, Ai Yamamoto, Sabine Stolz, Ursula Karamer, Mary S. Matsui, Akimichi Morita, Sijia Wang, Zhiwen Li, Li Jin, Jean Krutmann*, Tamara Schikowski, Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site. J Dermatol Sci, 2016 Sep;83(3):219-25. Anke Huls#, Andrea Vierkotter#, Wenshan Gao#, Ursula Kramer, Yajun Yang, Anan Ding, Sabine Stolz, Mary Matsui, Haiong Kan, Li Jin*, Sijia Wang*, Jean Krutmann*, Tamara Schikowski, Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians. J Invest Dermatol, 2016 May;136(5):1053-6. Lian Deng, Andres Ruiz-Linares, Shuhua Xu*, Sijia Wang*, Ancestry variation and footprints of natural selection along the genome in Latin American populations. Sci Rep, 2016 Feb 18;6:21766. Qianqian Peng#, Jinxi Li#, Jingze Tan#, Yajun Yang#, Manfei Zhang, Sijie Wu, Yu Liu, Juan Zhang, Pengfei Qin, Yaqun Guan, Yi Jiao, Zhaoxia Zhang, Pardis C. Sabeti, Kun Tang, Shuhua Xu, Li Jin*, Sijia Wang*, EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet, 2016 Jan;135(1):99-108. Miaozhu Li#, Andrea Vierkotter#, Tamara Schikowski#, Anke Huls, Anan Ding, Mary S. Matsui, Binwei Deng, Chuan Ma, Aiguo Ren, Juan Zhang, Jingze Tan, Yajun Yang, Li Jin, Jean Krutmann*, Zhiwen Li*, Sijia Wang*, Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci, 2015 Aug;79(2):148-54. Jingze Tan#, Qianqian Peng#, Jinxi Li#, Yanqun Guan, Liping Zhang, Yi Jiao, Yajun Yang, Sijia Wang*, Li Jin*, Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant. Sci China Life Sci, 2014 May;57(5):510-8. Jingze Tan#, Yanjun Yang#, Kun Tang, Pardis C.Sabeti, Li Jin*, Sijia Wang*, The adaptive variant EDARV370A is associated with straight hair in East Asians. Hum Genet, 2013 Oct;132(10):1187-91. Yana G. Kamberov#, Sijia Wang#, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas,Daniel E. Lieberman, Li Jin*, Clifford J. Tabin, Bruce A. Morgan*, Pardis C. Sabeti*, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell, 2013 Feb 14;152(4):691-702. Yungang He*, Wei R. Wang, Ran Li, Sijia Wang, Li Jin*, Genetic divergence disclosing a rapid prehistorical dispersion of Native Americans in Central and South America. PLoS One, 2012;7(9):e44788. Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*, Exploring Population Admixture Dynamics via Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. Am J Hum Genet, 2012 Nov 2;91(5):849-62. Carlos E.G. Amorim#, Sijia Wang#, Andrea R. Marrero, Tabita Hunemeier, Francisco M. Salzano, Ruiz-Linares Andres*, Maria Catira Bortolin*, X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations. Am J Hum Biol, 2011 May-Jun;23(3):299-304. Ningning Yang#, Stephene Mazieres#, Claudio Bravi, Nicolas Ray, Sijia Wang, Mari-Wyn Burley, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Giovanni Poletti, Kim Hill, Ana M. Hurtado, Maria L. Petzl-Erler, Luiza T. Tsuneto, William Klitz, Ramiro Barrantes, Elena Llop, Francisco Rothhammer, Damian Labuda, Francisco M. Salzano, Maria-Catira Bortolini, Laurent Excoffier, Jean Michel Dugoujon*, Andres Ruiz-Linares*, Contrasting patterns of nuclear and mtDNA diversity in Native American populations. Ann Hum Genet, 2010 Nov;74(6):525-38. Nicolas Ray, Daniel Wegmann, Nelson J.R. Fagundes, Sijia Wang, Andres Ruiz-Linares*, Laurent Excoffier*, A statistical evaluation of models for the initial settlement of the american continent emphasizes the importance of gene flow with Asia. Mol Biol Evol, 2010 Feb;27(2):337-45. Sijia Wang*, Gabriel Bedoya, Damian Labuda, Andres Ruiz-Linares*, Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol, 2010 Jul;142(3):476-80. Stephane Bourgeois, Vania Yotova, Sijia Wang, Sylvie Bourtoumieu, Claudia Moreau, Roman Michalski, Jean-Paul Moisan, Kim Hill, Ana M. Hurtado, Andres Ruiz-Linares, Damian Labuda*, X-chromosome lineages and the settlement of the Americas. Am J Phys Anthropol, 2009 Nov;140(3):417-28. Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M.Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Catira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, Jose E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier*, Andres Ruiz-Linares*, Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet, 2008 Mar 21;4(3):e1000037. Sijia Wang#, Cecil M. Lewis Jr#, Mattias Jakobsson#, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M.Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Catira Bortolini, Francisco M. Salzano, Maria Luiza Petzl-Erler, Luiza T. Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W. Feldman, Noah A. Rosenberg*, Andres Ruiz-Linares*, Genetic variation and population structure in Native Americans. PLoS Genet, 2007 Nov;3(11):e185.