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Key lab seminar by Dr. Keji Zhao,Oct. 10(Tuesday)
作者:    新闻时间:2017-09-26    已被阅读:224

Anyone who would like to have a talk with speaker,please feel free to contact Jing Mu(mujing@picb.ac.cn

Speaker:  Keji Zhao, PhD
                 Director and Senior Investigator, Systems Biology Center,
                 National Heart, Lung, and Blood Institute (NHLBI),  National Institutes of Health(NIH)


Web: https://www.nhlbi.nih.gov/research/intramural/researchers/pi/zhao-keji/

Time : 1:30-4:00 pm , Oct. 10(Tuesday)
Venue: Room 300, SIBS Main Building, Yueyang Road 320
Host:Prof. Gang Wei
           CAS-MPG Partner Institute for Computational Biology
 
Title: CTCF is a critical player in controlling gene expression noise

Abstract:

Recent studies indicate that even a homogeneous population of cells exhibit substantial cell-to-cell variation in gene expression. Our previous single-cell DNase-seq analysis suggests that chromatin states underlie the gene expression heterogeneity across different cells. CTCF is a key protein in chromatin organization in mammalian cells. I will present data to show that the enhancer-promoter interaction mediated by CTCF plays a critical role in controlling gene expression and reducing cell-to-cell variation of expression.

Bio:

Dr. Zhao’s research focuses on the epigenetic regulation of chromatin.  Understanding how epigenetic patterns are established during development and how improper epigenetic signals contribute to disease is the long-term goal for his lab. His lab developed the ChIP-SAGE, ChIP-Seq, MNase-Seq, and scDNase-seq techniques and also developed corresponding algorithms to analyze these data.  Using these approaches, Dr. Zhao’s lab has been pioneering whole-genome analyses of chromatin modifications in higher eukaryotic systems. By identifying these genome-wide epigenetic patterns, Dr. Zhao’s research has revealed numerous insights into the relationship between the epigenome, chromatin-modifying enzymes, and gene expression.

 

All are welcome!