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Key lab seminar by Dr. Lining Guo, Apr. 23
作者:lxma    新闻时间:2018-04-20    已被阅读:215

Time :  11:00 am , Apr. 23 (Monday)

 Venue: Room 315, SIBS Main Building, Yueyang Road 320

Host:  Prof. Zefeng Wang

             CAS-MPG Partner Institute for Computational Biology

Speaker:  Lining Guo, Ph.D.
                  Vice President of Project,
                  Management, Metabolon

 

Title: Metabolomics in Precision Medicine:

           From big data to individual genetic risk assessment and disease management

Abstract:  
The human metabolome represents a high resolution intermediate phenotype that bridges the impact of genetics, non-genetic factors, and health/disease end points. Genetic factors modifying the blood metabolome have been investigated through GWAS of common, low frequency, and rare genetic variants. Population analysis has further provided insights on the natural variation and regulation of human plasma
metabolome. Based on the knowledge we have learnt from large cohort studies, we combined metabolomics and whole genome/exome sequencing in individual clinical cases and provided novel insights to:
1) clarifying sequence variants of unknown significance (VUS).
2) Identifying metabolic defects in undiagnosed disease cases leading toclinical intervention
3) Identifying drug toxicity and responsiveness