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 韩敬东 研究员 研究组长 博士生导师 所长 计算生物学重点实验室主任

电子邮件  :jdhanpicb.ac.cn
联系电话  :021-54920458
课题组主页:http://www.picb.ac.cn/hanlab


    研究方向  

分子系统生物学


    研究领域  

主要从事分子系统生物学研究工作,具体包括:
1.研究生物网络的结构、动态及其功能;
2.通过表观组学、功能基因组学及整合网络分析,寻找衰老及干细胞分化相关的关键基因,并进一步研究分子及功能作用机制;
3.探求遗传基因网络中内在的安全稳定机制。


    获奖情况  

2015年,上海市领军人才
2014年,国家百千万人才工程,并获得国家“有突出贡献中青年专家”荣誉称号
2011年,上海市学术带头人
2009年,百人计划终期评估优秀
2006年,国家自然科学基金委员会杰出青年基金
2005年,中科院百人计划


    代表论文  

1.  Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40.

2. Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81.

3. Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J. Han*, Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc).

4. Weizhong Chen, Yi Liu, Shanshan Zhu, Christopher D. Green, Gang Wei, Jing-Dong J. Han*, Improved Nucleosome Positioning Algorithm iNPS for Accurate Nucleosome Positioning from Sequencing Data, Nature Communications 2014, doi:10.1038/ncomms5909.

5. Ming Su, Dali Han, Jerome D Boyd-Kirkup, Xiaoming Yu and Jing-Dong J Han*,Evolution of Alu towards enhancers, Cell Reports, 2014, 7(2): 376-385

6. Jin’e Li, Yi Liu, Min Liu and Jing-Dong J Han*,Functional dissection of regulatory models using gene expression data of deletion mutants, PLoS Genetics, 2013, 9(9): e1003757.

7. Wei Zhang, Yi Liu, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong J Han*, Integrating Genomic, Epigenomic and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian Cancer, Cell Reports, 2013, 4(3):542–553

8. Yi Liu, Nan Qiao, Shanshan Zhu, Ming Su, Na Sun, Jerome Boyd-Kirkup, Jing-Dong J. Han*. A novel Bayesian network inference algorithm for integrative analysis of heterogeneous deep sequencing data. Cell Research. 2013 Mar;23(3):440-3.

9. Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D.J. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions, Proc Natl Acad Sci U S A. 8;109(19):E1201-9.

10. Jin, C., Li, J., Green, C.D., Yu, X. , Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and  Han, J.-D.J *, Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 161-172.


    教育经历 & 学术背景  

2012.10-至今,上海科技大学生命科学与技术学院,教授.
2010.09-至今,中科院计算生物学重点实验室,主任.
2010.09-至今,中科院上海生科院计算生物学研究所,所长、研究员.
2005.03-2010.08,中科院遗传与发育生物学研究所,分子系统中心主任,研究员.
2002.09-2005.03,美国哈佛大学医学院,博士后.
2001.07-2002.08,美国CQOS公司,工程师.
2000.07-2001.06,美国Rare Medium公司,软件开发.
1999.01-2000.06,美国NorthStar科技公司,工程师.
1997.06-1998.12,美国洛克菲勒大学,博士后.