Welcome to PICB
  
  


Welcome to PICB Shanghai !
  首页 >    人才队伍   >  PI介绍   


 汪思佳 研究员 马普青年科学家小组组长 博士生导师

电子邮件  :wangsijiapicb.ac.cn
联系电话  :021-54920559
课题组主页:http://www.picb.ac.cn/dermatogenomics


    研究方向  

皮肤基因组学、表型组学


    研究领域  

在Paul-Gerson-Unna皮肤基因组学课题组,我们开发及运用系统组学分析方法及人工智能算法,利用人群队列产生的生物大数据,构建皮肤等外貌相关表型与基因、环境及其它相关表型的互作网络,建立预测个体健康状况的算法模型。


    获奖情况  

2013年入选国家“青年千人计划”。
2013年入选国家“自然科学基金优秀青年科学基金项目”。


    代表论文  

John R. Shaffer#, Jinxi Li#, Myoung Keun Lee, Jasmien Roosenboom, Ekaterina Orlova, Kaustabh Adhikari, 23andMe Research Team, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Paige E. Pfeffer, Christopher A. Wollenschlaeger, Jacqueline T. Hecht, George L. Wehby, Lina M. Moreno, Anan Ding, Li Jin, Yajun Yang, Jenna C. Carlson, Elizabeth J. Leslie, Eleanor Feingold, Mary L. Marazita, David A. Hinds, Timothy C. Cox, Sijia Wang*, Andres Ruiz-Linares, and Seth M. Weinberg*, Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment. Am J Hum Genet, 2017 Nov 21.

Anan Ding#, Yajun Yang#, Zhuohui Zhao#, Anke Huls, Andrea Vierkotter, Ziyu Yuan, Jing Cai, Juan Zhang, Wenshan Gao,Jinxi Li, Manfei Zhang, Mary Matsui, Jean Krutmann, Haidong Kan, Tamara Schikowski*, Li Jin*, Sijia Wang*, Indoor PM2.5exposure affects skin aging manifestation in a Chinese population. Sci Rep, 2017 Nov 10;7(1):15329.

Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang,Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*, Genetic history of Xinjiang's Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Mol Biol Evol, 2017 Oct 1;34(10):2572-2582.

Wenshan Gao#, Jingze Tan#, Anke Huls#, Anan Ding, Yu Liu, Mary S. Matsui, Andrea Vierkotter, Jean Krutmann, Tama ra Schikowski*, Li Jin*, Sijia Wang*, Genetic variants associated with skin aging in the Chinese Han population. J Dermatol Sci, 2017 Apr;86(1):21-29.

Manfei Zhang#, Bingjie Li#, Sijie Wu, Jingze Tan, Yajun Yang, Alessandra Marini, Andrea Vierkotter, Juan Zhang, Hui Li, Tamara Schikowski, Li Jin, Jean Krutmann, Sijia Wang*, A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol, 2017 Apr;137(4):979-982.

Manfei Zhang#, Sijie Wu#, Juan Zhang#, Yajun Yang#, Jingze Tan, Yu Liu, Haijuan Guan, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan*, Hui Li*, Sijia Wang*, Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics, 2016 Dec 20;43(12):702-704.

Sijie Wu#, Jingze Tan#, Yajun Yan#, Qianqian Peng, Manfei Zhang, Jinxi Li, Dongsheng Lu, Yu Liu, Haiyi Lou, Qidi Feng, Yan Lu, Yanqun Guan, Zhaoxia Zhang, Yi Jiao, Pardis Sabeti, Jean Krutmann, Kun Tang, Li Jin*, Shuhua Xu*,Sijia Wang*, Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet, 2016 Nov;135(11):1279-1286.

Anke Huls#, Andrea Vierkotter#, Wenshan Gao#, Ursula Kramer, Yajun Yang, Anan Ding, Sabine Stolz, Mary Matsui, Haiong Kan, Li Jin*, Sijia Wang*, Jean Krutmann*, Tamara Schikowski, Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians. J Invest Dermatol, 2016May;136(5):1053-6.

Lian Deng, Andres Ruiz-Linares, Shuhua Xu*, Sijia Wang*, Ancestry variation and footprints of natural selection along the genome in Latin American populations. Sci Rep, 2016 Feb 18;6:21766.

Qianqian Peng#, Jinxi Li#, Jingze Tan#, Yajun Yang#, Manfei Zhang, Sijie Wu, Yu Liu, Juan Zhang, Pengfei Qin, Yaqun Guan, Yi Jiao, Zhaoxia Zhang, Pardis C. Sabeti, Kun Tang, Shuhua Xu, Li Jin*, Sijia Wang*, EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet, 2016 Jan;135(1):99-108.

Miaozhu Li#, Andrea Vierkotter#, Tamara Schikowski#, Anke Huls, Anan Ding, Mary S. Matsui, Binwei Deng, Chuan Ma, Aiguo Ren, Juan Zhang, Jingze Tan, Yajun Yang, Li Jin, Jean Krutmann*, Zhiwen Li*, Sijia Wang*, Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci, 2015 Aug;79(2):148-54.

Jingze Tan#, Qianqian Peng#, Jinxi Li#, Yanqun Guan, Liping Zhang, Yi Jiao, Yajun Yang, Sijia Wang*, Li Jin*, Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant. Sci China Life Sci, 2014 May;57(5):510-8.

Jingze Tan#, Yanjun Yang#, Kun Tang, Pardis C.Sabeti, Li Jin*, Sijia Wang*, The adaptive variant EDARV370A is associated with straight hair in East Asians. Hum Genet, 2013 Oct;132(10):1187-91.

Yana G. Kamberov#, Sijia Wang#, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas,Daniel E. Lieberman, Li Jin*, Clifford J. Tabin, Bruce A. Morgan*, Pardis C. Sabeti*, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell, 2013 Feb 14;152(4):691-702.

Carlos E.G. Amorim#, Sijia Wang#, Andrea R. Marrero, Tabita Hunemeier, Francisco M. Salzano, Ruiz-Linares Andres*, Maria Catira Bortolin*, X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations. Am J Hum Biol, 2011 May-Jun;23(3):299-304.

Sijia Wang*, Gabriel Bedoya, Damian Labuda, Andres Ruiz-Linares*, Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol, 2010 Jul;142(3):476-80.

Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M.Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Catira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, Jose E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier*, Andres Ruiz-Linares*, Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet, 2008 Mar 21;4(3):e1000037.

Sijia Wang#, Cecil M. Lewis Jr#, Mattias Jakobsson#, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M.Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Catira Bortolini, Francisco M. Salzano, Maria Luiza Petzl-Erler, Luiza T. Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W. Feldman, Noah A. Rosenberg*, Andres Ruiz-Linares*, Genetic variation and population structure in Native Americans. PLoS Genet, 2007 Nov;3(11):e185.


    教育经历 & 学术背景  

中国科学院-马普学会计算生物学伙伴研究所研究员,博士生导师。于英国杜伦大学获得生物人类学硕士学位,于伦敦大学获得人类遗传学博士学位,后于美国哈佛大学及麻省理工-哈佛博德研究所从事博士后研究。

2012年被中科院与德国马普学会联合专家组遴选为马普青年科学家小组组长,回国于中科院马普计算生物学伙伴研究所创建Paul Gerson Unna皮肤基因组学课题组。入选“国家青年千人计划”,先后获得国家基金委“优秀青年科学基金”与“重大研究计划”资助。

在Cell、PLoS Genet、J Invest Dermatol等国际知名期刊上发表论文二十余篇,论文累计引用1000余次。并受邀成为Cell、Nat Genet、Elife、Curr Biol、PLoS Genet、Genome Res等10余个国际知名杂志的审稿人。担任Ann Hum Genet杂志的资深副主编。

目前课题组的主要科研方向为开发及运用整合大数据的组学手段,依托大型人类群体队列,寻找影响皮肤等外貌相关表型的遗传因素,并研究其进化意义。