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 汪思佳 研究员 马普青年科学家小组组长 博士生导师

电子邮件  :wangsijiapicb.ac.cn
联系电话  :021-54920559
课题组主页:http://www.picb.ac.cn/dermatogenomics


    研究方向  

皮肤基因组学


    研究领域  

在Paul-Gerson-Unna皮肤基因组学课题组,我们开发并结合应用最新的基因组学及计算遗传学等手段,依托大型人类群体队列,从分子遗传学的角度,对皮肤毛发等外貌特征的生物学特性进行研究。
1、开发并结合应用最新的基因组学手段,寻找导致皮肤毛发等外貌特征多样性的基因.
2、基因与环境的互作对皮肤衰老等外貌特征的影响.
3、皮肤毛发等外貌相关特征的选择、适应、及进化.


    获奖情况  

2013年入选国家“青年千人计划”。
2013年入选国家“自然科学基金优秀青年科学基金项目”。


    代表论文  

Wenshan Gao#, Jingze Tan#, Anke Huls#, Anan Ding, Yu Liu, Mary S. Matsui, Andrea Vierkotter, Jean Krutmann, Tamara Schikowski*, Li Jin*, Sijia Wang*, Genetic variants associated with skin aging in the Chinese Han population. J Dermatol Sci, 2017 Apr;86(1):21-29.

Manfei Zhang#, Bingjie Li#, Sijie Wu, Jingze Tan, Yajun Yang, Alessandra Marini, Andrea Vierkotter, Juan Zhang, Hui Li, Tamara Schikowski, Li Jin, Jean Krutmann, Sijia Wang*, A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol, 2016 Dec 20.

Manfei Zhang#, Sijie Wu#, Juan Zhang#, Yajun Yang#, Jingze Tan, Yu Liu, Haijuan Guan, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan*, Hui Li*, Sijia Wang*, Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics, 2016 Dec 20;43(12):702-704.

Sijie Wu#, Jingze Tan#, Yajun Yan#, Qianqian Peng, Manfei Zhang, Jinxi Li, Dongsheng Lu, Yu Liu, Haiyi Lou, Qidi Feng, Yan Lu, Yanqun Guan, Zhaoxia Zhang, Yi Jiao, Pardis Sabeti, Jean Krutmann, Kun Tang, Li Jin*, Shuhua Xu*,Sijia Wang*, Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet, 2016 Nov;135(11):1279-1286.

Andrea Vierkotter#, Anke Huls#, Ai Yamamoto, Sabine Stolz, Ursula Karamer, Mary S. Matsui, Akimichi Morita, Sijia Wang, Zhiwen Li, Li Jin, Jean Krutmann*, Tamara Schikowski, Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site.J Dermatol Sci, 2016 Sep;83(3):219-25.

Anke Huls#, Andrea Vierkotter#, Wenshan Gao#, Ursula Kramer, Yajun Yang, Anan Ding, Sabine Stolz, Mary Matsui, Haiong Kan, Li Jin*, Sijia Wang*, Jean Krutmann*, Tamara

Schikowski, Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians. J Invest Dermatol, 2016 May;136(5):1053-6.

Lian Deng, Andres Ruiz-Linares, Shuhua Xu*, Sijia Wang*, Ancestry variation and footprints of natural selection along the genome in Latin American populations. Sci Rep, 2016 Feb 18;6:21766.

Qianqian Peng#, Jinxi Li#, Jingze Tan#, Yajun Yang#, Manfei Zhang, Sijie Wu, Yu Liu, Juan Zhang, Pengfei Qin, Yaqun Guan, Yi Jiao, Zhaoxia Zhang, Pardis C. Sabeti, Kun Tang, Shuhua Xu, Li Jin*, Sijia Wang*, EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet, 2016 Jan;135(1):99-108.

Miaozhu Li#, Andrea Vierkotter#, Tamara Schikowski#, Anke Huls, Anan Ding, Mary S. Matsui, Binwei Deng, Chuan Ma, Aiguo Ren, Juan Zhang, Jingze Tan, Yajun Yang, Li Jin, Jean Krutmann*, Zhiwen Li*, Sijia Wang*, Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci, 2015 Aug;79(2):148-54.

Jingze Tan#, Qianqian Peng#, Jinxi Li#, Yanqun Guan, Liping Zhang, Yi Jiao, Yajun Yang, Sijia Wang*, Li Jin*, Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant. Sci China Life Sci, 2014 May;57(5):510-8.

Jingze Tan#, Yanjun Yang#, Kun Tang, Pardis C.Sabeti, Li Jin*, Sijia Wang*, The adaptive variant EDARV370A is associated with straight hair in East Asians. Hum Genet, 2013 Oct;132(10):1187-91.

Yana G. Kamberov#, Sijia Wang#, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas,Daniel E. Lieberman, Li Jin*, Clifford J. Tabin, Bruce A. Morgan*, Pardis C. Sabeti*, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell, 2013 Feb 14;152(4):691-702.

Yungang He*, Wei R. Wang, Ran Li, Sijia Wang, Li Jin*, Genetic divergence disclosing a rapid prehistorical dispersion of Native Americans in Central and South America. PLoS One, 2012;7(9):e44788.

Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*, Exploring Population Admixture Dynamics via Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. Am J Hum Genet, 2012 Nov 2;91(5):849-62.

Carlos E.G. Amorim#, Sijia Wang#, Andrea R. Marrero, Tabita Hunemeier, Francisco M. Salzano, Ruiz-Linares Andres*, Maria Catira Bortolin*, X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations. Am J Hum Biol, 2011 May-Jun;23(3):299-304.

Ningning Yang#, Stephene Mazieres#, Claudio Bravi, Nicolas Ray, Sijia Wang, Mari-Wyn Burley, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Giovanni Poletti, Kim Hill, Ana M. Hurtado, Maria L. Petzl-Erler, Luiza T. Tsuneto, William Klitz, Ramiro Barrantes, Elena Llop, Francisco Rothhammer, Damian Labuda, Francisco M. Salzano, Maria-Catira Bortolini, Laurent Excoffier, Jean Michel Dugoujon*, Andres Ruiz-Linares*, Contrasting patterns of nuclear and mtDNA diversity in Native American populations. Ann Hum Genet, 2010 Nov;74(6):525-38.

Nicolas Ray, Daniel Wegmann, Nelson J.R. Fagundes, Sijia Wang, Andres Ruiz-Linares*, Laurent Excoffier*, A statistical evaluation of models for the initial settlement of the american continent emphasizes the importance of gene flow with Asia. Mol Biol Evol, 2010 Feb;27(2):337-45.

Sijia Wang*, Gabriel Bedoya, Damian Labuda, Andres Ruiz-Linares*, Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol, 2010 Jul;142(3):476-80.

Stephane Bourgeois, Vania Yotova, Sijia Wang, Sylvie Bourtoumieu, Claudia Moreau, Roman Michalski, Jean-Paul Moisan, Kim Hill, Ana M. Hurtado, Andres Ruiz-Linares, Damian Labuda*, X-chromosome lineages and the settlement of the Americas. Am J Phys Anthropol, 2009 Nov;140(3):417-28.

Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M.Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Catira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, Jose E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier*, Andres Ruiz-Linares*, Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet, 2008 Mar 21;4(3):e1000037.

Sijia Wang#, Cecil M. Lewis Jr#, Mattias Jakobsson#, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M.Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Catira Bortolini, Francisco M. Salzano, Maria Luiza Petzl-Erler, Luiza T. Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W. Feldman, Noah A. Rosenberg*, Andres Ruiz-Linares*, Genetic variation and population structure in Native Americans. PLoS Genet, 2007 Nov;3(11):e185.