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 王鹏 平台研究组长 生物医学大数据中心

电子邮件  :wangpengpicb.ac.cn
联系电话  :
课题组主页:http://www.biosino.org/node


    研究方向  

(1) 计算生物学

(2)系统生物学


    研究领域  

系统生物学,基于大数据的调控网络构建,动态变化分析,多维网络组学在生物医学中的应用


    获奖情况  

2013年入选中科院百人计划


    代表论文  

1. M. Xue, H. Liu, L. Zhang, H. Chang, Y. Liu, S. Du, Y. Yang, P. Wang#, Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer. Nature Communications 11, 14917 (Apr 11, 2017).

2. Chang H, Liu Y, Xue M, Liu H, Du S, Zhang L, et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic acids research 2016, 44(6): 2514-2527.

3. Li L, Wang D, Xue M, Mi X, Liang Y, Wang P. 3'UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network. Scientific reports 2014, 4: 5406.

4. Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I,Cheroutre H: Transcriptional reprogramming of mature CD4? helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. (Nat Immunol . 2013 14(3):281-9).

5. Chen C, Dow C, Wang P, Sidney J, Read A, Harmsen AG, Samuel JE, Peters B: Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. 2011. (PLoS One, 2011 Mar15;6(3):e17712)

6. Wang P, Sidney J, Sette A, Peters B: Peptide binding predictions for all HLA class II loci. 2010. (BMC Bioinformatics. 2010; 11: 568)

7. Zhang H, Wang P, Papangelopoulos N, Xu Y, Sette A, Bourne PE, Lund O, Ponomarenko J, Nielsen M, Peters B: Limitations of ab initio predictions of peptide binding to MHC class II molecules. PLoS One. 2010, 5(2):e9272. (co-first author)

8. Wang P, Sidney J, Dow C, Mothe B, Sette A, Peters B: A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol 2008, 4(4):e1000048.

9. Wang P, Yan B, Guo JT, Hicks C, Xu Y:Structural genomics analysis of alternative splicing and application to isoform structure modeling. Proc Natl Acad Sci U S A 2005, 102(52):18920-18925.


    教育经历 & 学术背景  

教育经历

1996年本科毕业于北京大学生物系

2001博士毕业于UW-Madison

2002年获得康奈尔大学计算机硕士学位

2002-2011年先后在佐治亚大学和La Jolla Institute for Allergy & Immunology从事博士后研究。


工作经历

2017年-至今,马普计算生物学研究所,PI, 研究员

2011年-2017年,中科院上海高等研究院,PI,研究员