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  Homepage >    People   >  Principal Investigators   


 XU Shuhua
 Ph.D.,Professor,Principal Investigator,Director

Email : xushuapicb.ac.cn
Lab Name :  Population Genomics
Group Page : http://www.picb.ac.cn/PGG


    Research Areas  

Genetic Admixture and Microevolution of Human Populations


    Interests  

Officially set up in January 2012 by Prof. Dr. Shuhua Xu at the Partner Institute for Computational Biology, The Max Planck Independent Research Group on Population Genomics focused on population genomics research of human admixture history and biological adaptation to the local environment.

Population Genomics is a disciplinary to infer population genetic and evolutionary parameters from genome-wide data sets. The ultimate goal of this research group is to understand microevolution mechanisms in human, while genetic admixture was taken as a cut-in point to pursue this ambition. Dr. Xu's group is using computational approaches and developing new methods to dissect genetic architecture of human populations, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence.

Specifically, Dr. Xu's group is working on several projects, focusing on theoretical modeling of human population admixture, statistical inference of human migration history and detection of footprints of natural selection in human genome, respectively.

Over the past five years, Dr. Xu's group systematically examined linage disequilibrium (LD) and genetic structure of admixed populations, revealed the fine-scale genetic structure and the admixture pattern of Asian populations from a genome-wide level, established novel methods to detect the natural selection in admixed populations and infer population history using genetic admixture and recombination information in admixed genomes. The group has published more than 60 peer-reviewed papers in high-impact international scientific journals such as Science, PNAS, Am.J.Hum.Genet., Genome Res., Hum.Mol.Genet., Mol.Biol.Evol., PLoS and BMC series, etc.


    Awards  

2016: Shanghai Academic Research Leader
2015: Distinguished Young Scholars of National Science Fund
2015: 2nd Class Prize of National Natural Science Award
2015: Distinguish Principal Investigator of Chinese Academy of Sciences (CAS)
2015: Outstanding Member of the 1st Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association (CAS)
2015: Expert of Pudong New Area Science and Technology Development Fund
2013: Youth Committee Member of the 9th Council Meeting of Chinese Society of Genetics
2013: Outstanding Member of Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association (CAS)
2013: The National Top-notch Young Innovative Talent supported by The "Ten-Thousand-Talents" Project (Wanren Jihua)
2012: Distinguish Young Scientist, Chinese Academy of Sciences
2012: Nomination Prize of the 6th Shanghai Scientific Young Elites Program (Shanghai Government)
2012: Thesis Advisor for 2012 SIBS-Eli Lilly Outstanding Graduate Thesis Award Winner (US)
2012: CAS Young Scientists Award (CAS, Shanghai Branch)
2012: 1st Class Prize of Natural Science Award, Ministry of Education.
2011: The 1st Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association (CAS)
2011: Top 100 National Excellent Doctoral Dissertation Award in China (Ministry of Education of China & Academic Degrees Committee of the State Council)
2011: Shanghai Rising-Star, bestowed by Science and Technology Commission of Shanghai Municipality
2010: Award of the Excellent Doctoral Dissertation (Fudan University)
2009: Award of the Excellent Doctoral Dissertation of Shanghai (Shanghai Municipal Education Commissions)
2009: Sanofi Aventis (SA)-SIBS 2009 Young Faculty Award (France)
2009: Life Science Award, Shanghai, MEIJI Dairies Corp (Japan)
2009: Chia-Si Lu Scholarship of Chinese Academy of Sciences (CAS)


    Selected Publications  

1. Haiyi Lou, Yan Lu, Dongsheng Lu, Ruiqing Fu, Xiaoji Wang, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*. A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence. Am.J.Hum.Genet. 97(1):54-66. 2015.

2. Shuhua Xu*, Irina Pugach, Mark Stoneking, Manfred Kayser, Li Jin, The HUGO Pan-Asian SNP Consortium. Genetic Dating Indicates that the Asian-Papuan Admixture through Eastern Indonesia Corresponds to the Austronesian Expansion. PNAS 109(12):4574-4579. 2012.

3. Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*. Exploring Population Admixture Dynamics Using Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. Am.J.Hum.Genet. 91:849-862. 2012.

4. Wenfei Jin, Pengfei Qin, Haiyi Lou, Li Jin*, Shuhua Xu*. A Systematic Characterization of Genes Underlying both Complex and Mendelian Diseases. Hum.Mol.Genet. 21(7):1611-1624. 2012.
 
5. Wenfei Jin, Shuhua Xu*, Haifeng Wang, Yongguo Li, Yiping Shen, Bailin Wu, Li Jin*. Genome-Wide Detection of Natural Selection in African Americans Pre-and Post-Admixture. Genome Research 22:519-527. 2012.
 
6. Shuhua Xu*, Shilin Li, Yajun Yang, Jingze Tan, Haiyi Lou, Wenfei Jin, Ling Yang, Xuedong Pan, Jiucun Wang, Yiping Shen, Bailin Wu, Hongyan Wang, Li Jin*. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. Mol.Biol.Evol. 28:1003-1011. 2011.
 
7. The HUGO Pan-Asian SNP Consortium (Li Jin*, Edison T. Liu*, Mark Seielstad*, Shuhua Xu*; 93 authors from 10 countries). Mapping Genetic Diversity in Asia. Science 326:1541-1545. 2009.

8. Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin, Haiyi Lou, Ling Yang, Xiaohong Gong, Xuejun Zhang, Xianyong Yin, Yungang He, Yajun Yang , Yi Wang, Wenqing Fu, Yu An, Jingze Tan, Jiucun Wang, Ji Qian, Xin Zhang, Yangfei Sun, Hongyan Wang ,Bailin Wu , Li Jin*. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies. Am.J.Hum.Genet. 85:762-774. 2009.

9. Shuhua Xu, Li Jin*. A Genome-wide Analysis of Admixture in Uyghurs and a High-Density Admixture Map for Disease-Gene Discovery. Am.J.Hum.Genet. 83:322-336. 2008.

10. Shuhua Xu, Wei Huang, Ji Qian, Li Jin*. Analysis of Genomic Admixture in Uyghur and Its Implication in Mapping Strategy. Am.J.Hum.Genet. 82:883-894. 2008.


    Education & Academic Background  

Dr. Shuhua Xu is professor of human population genetics and Principal Investigator of Population Genomics Group at the CAS-MPG Partner Institute for Computational Biology. He is currently holding the position of Max-Planck Independent Research Group Leader and a Distinguished Adjunct Professorship at ShanghaiTech University. He received his PhD at Fudan University, China. His scientific research has focused on population genomics research of human admixture history and biological adaptation to the local environment. The ultimate goal of his research is to understand microevolution mechanisms in human, while genetic admixture was taken as a cut-in point to pursue this ambition. The Population Genomics Group led by Dr. Xu is using computational approaches and developing new methods to dissect genetic architecture of human populations, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence. Dr. Xu has authored many scientific papers published in Science, PNAS, The American Journal of Human Genetics, Genome Research, Molecular Biology and Evolution, Human Molecular Genetics, the PLoS and the BMC series. Dr. Xu serves as Editorial Board member of several international peer-reviewed journals such as Hereditas, Human Genomics, Frontier in Genetics, Hereditas, Molecular Genetics and Genomics, Scientific Reports etc. He is also a Section Editor of BMC Genetics.