Welcome to PICB
Home   |    About Us |   Research  |    People |    Education |  Cooperation |  Bio-Med Big Data Center |  Key Laboratory

Welcome to PICB Shanghai !
  Homepage >    People   >  Principal Investigators   

 Ph.D, Professor, Principal Investigator

Email : wuweipicb.ac.cn
Lab Name :  Systems Genomics and Precision Health
Group Page : http://www.picb.ac.cn/weiLab

    Research Areas  

(1) Systems Genomics

(2) Precision Health

(3) Bioinformatics


One of the big challenges in precision medicine is to determine the contribution of sequence variants in the genome to hereditary phenotypes and diseases. My research focus on understanding the mechanism of the complex traits, by investigating the molecular processes that link genotype to phenotype, identifying the underlying factors, and quantifying their contributions. I have experiences on investigating variation at the level of the genome, transcriptome and post-transcription regulation, which were integrated into higher-level phenotypes. My long-term goal is to dissect the mechanism of how phenotypic heterogeneity is generated, leading to understand the underlying basis of complex traits for human health and disease.


    Selected Publications  

1. Pelechano V.*, Wei W.* , Steinmetz L.M.: Widespread co-translational RNA decay reveals in vivo ribosome dynamics. Cell, 161:1400-1412 (2015).

2. Pelechano, V.*, Wei, W.* , Steinmetz, L.M. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature 497, 127-131 (2013).

3. Xu, Z.*, Wei, W.* , Gagneur, J., Perocchi, F., Clauder-Muenster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W., Steinmetz, L.M. Bidirectional promoters generate pervasive transcription in yeast. Nature 457, 1033-1037 (2009).

4. Wei, W. , McCusker, J.H., Hyman, R.H., Jones, T., Ning, Y., Cao, Z., Gu, Z., Bruno, D., Miranda, M., Nguyen, M., Wilhelmy, J., Komp, C., Tamse, R., Wang, X., Jia, P., Luedi, P., Oefner P.J., David, L., Dietrich, F.S., Li, Y., Davis, R.W., Steinmetz, L.M. Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Proc. Natl. Acad. Sci. USA 104, 12825-12830 (2007).

    Education & Academic Background  

2002 – 2007, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China , Ph. D in Bioinformatics
1998 – 2002, School of Life Sciences, Sichuan University, Sichuan, China, B.S. in Microbiology

Professional Experience
2017 – Present, Principal Investigator, CAS-MPG Partner institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2014 – 2017, Group Leader in Bioinformatics, Senior Research Scientist, Stanford Genome Technology Center, Stanford University
2011 – 2014, Research Associate, Stanford Genome Technology Center, Stanford University
2007 – 2011, Postdoctoral Fellow, Genome Biology Unit, European Molecular Biology Laboratory - EMBL Heidelberg