logoEukaryotic Transcriptomics (Yang Lab)

CAS-MPG Partner Institute for Computational Biology, SIBS, CAS

News

2018

March: Ying, Jia and Li have contributed an article in Nature Biotechnol. Contributions to Ying, Jia and Li.

January: Jian-Feng, Qin and Li have contributed a short article in Mol Cell. Congratulations to Jian-Feng, Qin and Li.

2017

December: Wei, Jia and Li have contributed an article in Nat Struct Mol Biol. Congratulations to Wei, Jia and Li.

Novermber: Zheng and Li have contributed an article in Mol Cell. Congratulations to Zheng and Li.

Novermber: Li has contributed a perspectives in Science. Congratulations to Li.

October: Our lab participated in city hiking and won the second and forth prizes.

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August: Wei, Jia and Li have contributed a letter in Cell Res. Congratulations to Wei, Jia and Li.

June: Qin, Ying and Li have contributed a mini review in Quantitative Biology. Congratulations to Qin, Ying and Li.

July: Congratulations on our recent Mol Cell paper! Our paper has been selected as “Featured Article” of the issue. Moreover, the first authors of the paper were invited to take part in “Meet the Authors” section on the Mol Cell website to share their experience and the stories behind the paper. Congratulations to Wei again!

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June: Li has contributed a review in Trends Genet. Congratulations to Li.

June: Wei, Jia and Li have contributed an article in Mol Cell. Congratulations to Wei, Jia and Li!

May: Rui has passed the dissertation defense! He becomes the Ph.D graduate of our lab! Congratulations to Rui!

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May: Rui and Li have contributed an article in Cell. Congratulations to Rui and Li!

February: Li has contributed a review in Trends Cell Biol. Congratulations to Li!

January: Jian-Feng, Qin and Li have contributed an article in Cell Disc. Congratulations to Jian-Feng, Qin and Li!

2016

December: Rui, Xu-Kai and Li have contributed an article in RNA Biol. Congratulations to Rui, Xu-Kai and Li!

Novermber: Xu-Kai, Zheng and Li took part in the Cold Spring Harbor Asia conference on RNA Biology and Li delivered a presentation.

Novermber: Rui and Wei participated in Cell Symposia Functional RNAs and Rui presented his latest public researches in the poster presentations.

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November: Our lab participated in city hiking and won the third prize.

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October: Zheng, Jian-Feng and Li have contributed an article in Mol Cell. Congratulations to Zheng, Jian-Feng and Li!

The authors have employed a variety of techniques including RNA immunoprecipitation and deep sequencing to explore the repertoire of snoRNA related lncRNAs. These approaches allowed the authors to identify a type of polycistronic transcript derived lncRNAs that are 5' snoRNA capped and 3' polyadenylated (SPAs). SPA processing is associated with nascent mRNA 3’ processing and kinetic competition between XRN2 trimming and Pol II elongation. Following cleavage/polyadenylation of its upstream gene, the downstream uncapped pre-SPA is trimmed by XRN2 until this exonuclease reaches the co-transcriptionally assembled snoRNP. This snoRNP complex prevents further degradation, generates a novel 5' end and allows continuous Pol II elongation. The imprinted 15q11-q13 encodes two SPAs that are deleted in Prader-Willi syndrome (PWS) patients. These PWS region SPAs, together with previously identified sno-lncRNAs (Yin et al., Mol Cell, 2012) form a nuclear accumulation that is enriched in multiple RNA binding proteins (RBPs) including TDP43, RBFOX2 and hnRNP M. Generation of a human PWS cellular model by depleting these lncRNAs results in altered patterns of RBPs binding and alternative splicing. Prader-Willi Syndrome is a multiple-system human disorder including global developmental delay, mental retardation, morbid obesity, and etc. These findings thus implicated previously unannotated class of lncRNAs in PWS pathogenesis during early embryonic development and adulthood.

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October: Zheng, Qin and Li have contributed a preview in Mol Cell. Congratulations to Zheng, Qin and Li.

September: Rui has obtained National Scholarship for Outstanding Graduate Student, Ministry of Education of the People's Republic of China. Congratulations to Rui!

July: Rui took part in the second circular RNA Research Forum and delivered a presentation.

June: Rui and Wei participated in the 2016 joint annual meeting of the RNA Society and the RNA Society of Japan and presented their latest public researches in the poster presentations.

June: We have published a collaborative work with Chen Lab in Genome Res. Congratulations to Xiao-Ou, Rui, Jia-Lin, Zheng and Li.

May: Xiao-Ou has passed the dissertation defense! He becomes the first Ph.D graduate of our lab! Congratulations to Xiao-Ou!

April: Welcome new graduate student Meng-Ran to join our group!

April: Our lab has contributed an article in Cell Reports. Congratulations to Wei, Jia-Lin and Li.

March: Our lab has contributed a letter in Cell Res. Congratulations to Rui, Xiao-Ou, Xu-Kai and Li.

March: Xiao-Ou has obtained 2016 Shanghai outstanding graduates and 2016 Shanghai tri-merit student honor award. Congratulations to Xiao-Ou.

March: Welcome new graduate students Kai-Xuan and Ying to join our group!

January: Li has contributed a chapter of Long Non-Coding RNAs. Congratulations to Li!

January: Rui and Li have contributed an article in Cell Res. Congratulations to Rui and Li!

2015

December: We welcome new Research Associate Jia to join our group!

October: Li has contributed a review on lncRNA biogenesis in WIREs RNA. Congratulations to Li.

August: Li has contributed an article in Genome Res. Congratulations to Li!

August: Xiao-Ou has been selected as a recipient of the 2015 Ray Wu Prize for Excellent in Life Sciences. Congratulations to Xiao-Ou!

August: Li has contributed a review in Curr Opin Genet Dev. Congratulations to Li!

July: We have published a collaborative work on haploid embryonic stem cells with Yang Lab in Cell Stem Cell. Congratulations to Rui and Li.

June: Li and Ling-Ling have contributed a preview in Mol Cell.

April: Li and Ling-Ling have contributed a review on circRNA biogenesis in RNA Biology.

April: We welcome new graduate students Xu-Kai and Jia-Lin to join our group!

April: Our website has been updated with wholly new engine and templates. Cheer Up!

March: We have published a collaborative work with Chen Lab in Genes & Dev. Congratulations to Wei and Li.

2014

December: Zheng has passed his prelim! Congratulations to Zheng!

September: We have published a collaborative work on circular RNAs with Chen Lab in Cell. Congratulations to Xiao-Ou and Li.

May: We have published a collaborative work on sno-lncRNAs with Chen Lab in BMC Genomics. Congratulations to Xiao-Ou and Li.

May: Rui and Qin of our group have passed the mid-term review. Congratulations to Rui and Qin!

April: Welcome new graduate student Zheng to join our group!

March: We have published a collaborative work with Chen Lab in BMC Genomics. Congratulations to Xiao-Ou and Li.

2013

December: Rui and Qin of our group have passed their prelim. Congratulations to Rui and Qin!

October: Hua-Hong has a cute baby boy. Cheer up!

September: We have published a collaborative work on circular intronic RNAs with Chen Lab in Mol Cell. Congratulations to Xiao-Ou, Shanshan and Li.

August: Our sno-lncRNA paper published in Mol Cell was recently selected as one of Best of 2012 by Mol Cell.

June: Xiao-Ou has obtained the Best Poster Awards in The 2013 CAS-MPG Partner Institute for Computational Biology Scientific Exchange Meeting. Congratulations to Xiao-Ou!

March: Xiao-Ou has passed his mid-term evaluation. Congratulations to Xiao-Ou!

April: We have published a collaborative work on RNA editing with Chen Lab in BMC Genomics. Congratulations to Shanshan and Li.

April: We welcome new graduate students Rui and Qin to join our group!

February: Our invited review on long noncoding RNAs was published. Congratulations to Shanshan, Xiao-Ou, Li!

2012

December: Li was invited to give comments on Diffculties in RNA editing study in Nat Biotechnol. Congratulations to Li!

December: Congratulations to Xiao-Ou for passing his prelim!

October: We published a collaborative work on sno-lncRNA with Chen Lab in Mol Cell. Congratulations to Li.

October: Chen Lab and our lab had an enjoyable joint lab retreat in Suzhou.


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