Group of Clinical Genomic Networks – Christine Nardini

Department of  Molecular Systems Biology - CAS-MPG Partner Institute for Computational Biology



Christine Nardini, PhD – Principal Investigator

Address: Room #334, 2nd Floor
PICB 320 Yue Yang Road, 200031 Shanghai, PRC
Tel: +86 21 54920485

e-mail: christine (#)picb(*)ac(*)cn

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current position

2008-now. Principal Investigator at PICB CAS-MPG (Chinese Academy of Science – German Max Plank Society), in Shanghai (China)

2006- 2008. Research Assistant at the Department of Electronic Informatics and Systems (DEIS) at the University of Bologna (Italy).


2003-2005 -  PhD in Electronics and Informatics  at University of Bologna. Thesis Title: “Statistical-Computational Techniques for Extraction of Functional Genomic Units from Microarray Experiments”. Supervisor: Prof. Luca Benini.

1999 National Habilitation to Engineers Professional Activity.

1992-1998 –Master Degree in Electrical Engineering  – Biomedical specialization at the University of Bologna (90/100). Thesis title: “Identification of non-linear dynamics through space and time dependent neural networks”. Tutor: Prof. Mauro Ursino

1992 – BS Degree at Istituto N. Copernico in  Bologna (60/60).


Collaborator at the Telethon Institute for Genetics and Medicine (TIGEM) in Naples.

Collaboration with Unità di Genetica Medica del Policlinco S. Orsola (Bologna, Italy) and European Genetic Foundation (EGF).

Collaboration with Embryology Department and DAMA (DAta Mining and Analysis) Telethon Facility at University of Ferrara (Italy) for research on multigenic hereditary diseases.

Collaboration with Ecole Polythecnique Fédérale de Lausanne (EPFL, CH) on Data Mining for high throughput biological sensors.

Internship and collaboration with The Center for Translational Medical Systems at University of California San Diego (UCSD, USA), with Michael D. Kuo, MD, for the bioinformatics side of the development of Radiogenomics.

Visiting researcher at the Computer Science Department at Stanford University (CA, USA), with Prof Giovanni de Micheli. For the development of data mining algorithms to be applied to microarrays for gene expression analyses.

Research activity

Current: See Here


-         Synthetic Biology: project, design and construction of a genetic Schmitt Trigger for applications in molecular biology and eventually medicine (presented at the international Genetically Engineered Machine Competition, iGEM2007). Funded by SYNBIOCOM, European Grant.

-         Multigenic Hereditary Diseases research. In collaboration with the Genetic Medical Unit at S..Orsola Hospital in Bologna and with Data Mining of DNA microarray (DAMA) Telethon Facility  at Ferrara University. We developed generated an approach enabling geneticists to narrow down to a few candidates the focus of gene hunting for multigenic  pathologies. The approach is based on the implementation of an original pipeline of statistical tests for the generation of a global statistical score for the evaluation of the similarity among gene clusters of different origins.  Funded by PRIN 2004, National Grant.

-         Gene-Network Reverse-Engineering. In collaboration with Telethon Institute for Genetic Medicine (TIGEM) in Naples, contribution to the definition of ordinary differential equation based approaches to inference of gene network based on steady-state microarray data .

-         Clinical Genomics. In collaboration with The Center for Translational Medical Systems at UCSD, contribution to the bioinformatics side of the  discovery of molecular surrogates in the diagnosis of brain tumors Glioblastoma Multiforme (GBM). Several solution and approaches have been devised or adapted to further characterize the relationship between the molecular and radiological paradigm, including the definition of alternative approaches for the selection of meaningful genes extracted from high throughput experiments, accounting for the problem of the multiple hypothesis correction.

-         Data Mining. In collaboration with the CS department at  Stanford University, development and implementation of a bi-clustering algorithm, to group genes with similar behavior based on activation profiles measured with microarray experiments. Bi-clustering algorithms, conversely to traditional clustering algorithms, allow the extraction of co-expressed genes, working simultaneously on genes and samples dimension. The algorithms uses Zero-Suppressed Binary Decision Diagrams. 


·         2012 Lecturer for a module of the “Bioinformatics Algorithms” 1st year PICB course

·         2011 Lecturer for a module of the “Bioinformatics Algorithms” 1st year PICB course.

·         2011 Lecturer  in the programme  International Max Planck Research School (IMPRS)

·         2009 Lecturer for a module of the “Bioinformatics Algorithms” 1st year PICB course.

·         2006 – Conference RSNA Radiological Society of North America, Faculty for the refresher course ‘Integrating Cancer Genomics and Radiological Imaging: Practical Answers to Complex Problems (How-to Workshop)

·         2006-2008 Professor for the module on bioinformatics for systems biology for the courseBiosensori at the University of Bologna for Master Degree in Bioinformatics at the Faculty of Mathematics Physics and Natural Sciences. For information and program see here (official website) and here (lectures material)).


·         2012-2015: co-PI in the project n. 294935 “KEPAMOD—Knowledge exchange in processing and analysis of multi-omic data” funded under the Marie Curie Actions—International Research Staff Exchange Scheme (IRSES)

·         2011- entered the consortium BP-TCM ( funded by FP7 EU, Work Package 8 - Functional genomics in studies of acupuncture-moxibustion (Grant No. 223154, non-beneficiary member)

·         2011-2012 co-Principal investigator in the Nanotera Sino Swiss Science and technology Consortium Pilot grant “intelligent needle with wireless connection to internet for biophysical bases of acupuncture”.

·         2012-2015 Principal Investigator for the research entitled “Autoimmune Disease Therapies: variations on the microbiome in rheumatoid arthritis” funded by the National Sciences Foundation of China (NSFC) (grant n. 31171277). 

·         2011 Principal Investigator for the research entitled “Systems biology, computational immunology” sponsored by the Visiting Professor Fellowship for International Scientists, awarded to Dr. Paolo Tieri  from University of Bologna. Chinese Academy of Sciences, 2011

·         2011-2013 Participant in the project, “Systems Biology approach for genotype to phenotype modeling” Funded by Chinese Academy of Sciences (CAS)

·         2011-2013 Principal investigator of the project “Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data”, funded by the National Science Foundation of China (NSFC) (grant n. 31070748),

·         2009-2011 Principal investigator “Nano-structured Bio-Chip development for Stem Cells Monitoring” Funded by the Sino-Swiss Science and Technology Cooperation Project (SSSTC).

·         2009-2011 Principal investigator for the research entitled “Applying network analysis methods to reverse-engineering of gene-networks” awarded to J. E. Dent and Funded by Science and Technology Fellowship Programme (SSTC), FP7, European Community.


See here