Population Genomics Group (PGG)

"Population Genomics: A Bridge from Evolutionary History to Genetic Medicine" (L.B.Jorde, 2001)

 

Recent Publications

To contact Me:

Tel: +86-21-549-20479

Fax: +86-21-549-20451

E-mail: xushua@picb.ac.cn

Wenfei Jin, Shuhua Xu*, Haifeng Wang, Yongguo Li, Yiping Shen, Bailin Wu, Li Jin*. 2011. A Genome-Wide Detection of Natural Selection in African Americans Pre-and Post-Admixture. Genome Res. (doi:10.1101/gr.124784.111).

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Xiong Yang, Shuhua Xu*, The HUGO Pan-Asian SNP Consortium. 2011. Identification of Close Relatives in the HUGO Pan-Asian SNP Database. PLoS One (10.1371/journal.pone.0029502).

             [Abstract]       [Full text]       [PDF]

 

Wenfei Jin, Pengfei Qin, Haiyi Lou, Li Jin*, Shuhua Xu*. 2011. A Systematic Characterization of Genes Underlying both Complex and Mendelian Diseases. Hum.Mol.Genet. (doi:10.1093/hmg/DDR599).

             [Abstract]       [Full text]       [PDF]      [Supplementary Material]   

 

Haiyi Lou, Shilin Li, Yajun Yang, Longli Kang, Xin Zhang, Wenfei Jin, Bailin Wu , Li Jin*, Shuhua Xu*. 2011. A Map of Copy Number Variations in Chinese Populations. PLoS One 6 (11): e27341.

             [Abstract]       [Full text]       [PDF]

 

Shuhua Xu*, Li Jin. 2011. Chromosome-Wide Haplotype Sharing: A Measure Integrating Recombination Information to Reconstruct the Phylogeny of Human Populations. Ann.Hum.Genet. 75 (6): 694-706.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]    [Cover]

 

Shuhua Xu*, Shilin Li, Yajun Yang, Jingze Tan, Haiyi Lou, Wenfei Jin, Ling Yang, Xuedong Pan, Jiucun Wang, Yiping Shen, Bailin Wu, Hongyan Wang, Li Jin*. 2011. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. Mol.Biol.Evol. 28: 1003-1011.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Chumpol Ngamphiw, Anunchai Assawamakin, Shuhua Xu, Philip J. Shaw, Jin Ok Yang, Ho Ghang, Jong Bhak, Edison Liu, Sissades Tongsima*, The HUGO Pan-Asian SNP Consortium. 2011. PanSNPdb: The Pan-Asian SNP Genotyping Database. PLoS One 6 (6): e21451.

             [Abstract]       [Full text]       [PDF]

 

Pankaj Jha, Swapnil Sinha, Kanika Kanchan, Tabish Qidwai, Ankita Narang, Prashant Kumar Singh, Sudhanshu S. Pati, Sanjib Mohanty, Saroj K. Mishra, Surya K. Sharma, Shally Awasthi, Vimala Venkatesh, Sanjeev Jain, Analabha Basu, Shuhua Xu, Indian Genome Variation ConsortiumMitali Mukerji, Saman Habib. 2011. Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria. Infection, Genetics and Evolution 12: 142-148 (10.1016/j.meegid.2011.11.001).

             [Abstract]       [Full text]       [PDF]

 

Xiaoyun Cai, Zhendong Qin, Bo Wen, Shuhua Xu, Yi Wang, Yan Lu, Lanhai Wei, Chuanchao Wang, Shilin Li, Xingqiu Huang, Li Jin, Hui Li*, the Genographic Consortium. 2011. Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes. PLoS One 6 (8): e24282.

             [Abstract]       [Full text]       [PDF]

 

Wan Isa Hatin, Ab Rajab Nur-Shafawati, Mohd-Khairi Zahri, Shuhua Xu, Li Jin, Soon-Guan Tan, Mohammed Rizman-Idid, Bin Alwi Zilfalil, The HUGO Pan-Asian SNP Consortium". 2011. Population Genetic Structure of Peninsular Malaysia Malay Sub-Ethnic Groups. PLoS One 6(4): e18312.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Frederick Delfin, Jazelyn M Salvador, Gayvelline C Calacal, Henry B Perdigon, Kristina A Tabbada, Lilian P Villamor, Saturnina C Halos, Ellen Gunnarsdo´ ttir, Sean Myles, David A Hughes, Shuhua Xu, Li Jin, Oscar Lao4, Manfred Kayser, Matthew E Hurles, Mark Stoneking and Maria Corazon A De Ungria*. 2011. The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups. Eur.J.Hum.Genet. 19: 224-230.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu*, Sanchit Guputa and Li Jin*. 2010. PEAS V1.0: A Package for Elementary Analysis of SNP Data. Mol.Ecol.Res. 10:1085-1088.

             [Abstract]       [Full text]       [PDF]       [Software download]

 

Shuhua Xu, Daoroong Kangwanpong, Mark Seielstad, Metawee Srikummool, Jatupol Kampuansai, Li Jin. 2010. The HUGO Pan-Asian SNP Consortium. Genetic Evidence Supports Linguistic Affinity of Mlabri — a Hunter-Gatherer Group in Thailand. BMC Genet. 11:18.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

The HUGO Pan-Asian SNP Consortium (Li Jin*, Edison T. Liu*, Mark Seielstad*, Shuhua Xu*; 93 authors from 10 countries). 2009. Mapping Genetic Diversity in Asia. Science 326: 1541-1545.

             [Abstract]     [Full text]     [PDF]     [Supplementary Material]    [News]

 

Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin, Haiyi Lou, Ling Yang, Xiaohong Gong, Hongyan Wang, Yiping shen, Xuedong Pan, Yungang He, Yajun Yang, Yi Wang, Wenqing Fu, Yu An, Jiucun Wang, Jingze Tan, Ji Qian, Xiaoli Chen, Xin Zhang, Yangfei Sun, Xuejun Zhang, Bailin Wu, Li Jin. 2009. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies. Am.J.Hum.Genet.  85:762-774.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu and Li Jin, 2009. Genetic Landscape of Eurasia and ‘‘Admixture’’ in Uyghurs Response. Am.J.Hum.Genet. 85:937-939.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu, Wenfei Jin, Li Jin 2009. Haplotype Sharing Analysis Showing Uyghurs Are Unlikely Genetic Donors. Mol.Biol.Evol. 26(10): 2197-2206.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu, Li Jin. 2009. Computational Biology—Review and Prospects. Science (KEXUE). 61(4):34-37.

             [Link]       [PDF]

 

Yungang He, Shuhua Xu, Chuan Jia, Li Jin 2009. A design of multi-source samples as a shared control for association studies in genetically stratified populations. Cell Research 19:913-915.

             [Abstract]       [Full text]       [PDF]

 

Shuhua Xu, Li Jin. 2008. A Genome-wide Analysis of Admixture in Uyghur and a High-Density Admixture Map for Disease-Gene Discovery. Am.J.Hum.Genet. 83:322-336.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu, Wei Huang, Ji Qian, Li Jin. 2008. Analysis of Genomic Admixture in Uyghur and Its Implication in Mapping Strategy. Am.J.Hum.Genet. 82:883-894.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Fuzhong Xue, Yi Wang, Shuhua Xu, Feng Zhang, Bo Wen, Xuesen Wu, Ming Lu, Ranjan Deka, Ji Qian, and Li Jin. 2008. A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages. Eur.J.Hum.Genet. 16:705-717.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Shuhua Xu, Wei Huang, Haifeng Wang, Yungang He, Ying Wang, Yi Wang, Ji Qian, Momiao Xiong, Li Jin. 2007. Dissecting Linkage Disequilibrium in African American Genomes: Roles of Markers and Individuals. Mol.Biol.Evol. 24:2049-2058.

             [Abstract]       [Full text]       [PDF]       [Supplementary Material]

 

Qin Zan, Bo Wen, Yungang He, Yi Wang, Shuhua Xu, Ji Qian, Daru Lu, and Li Jin. 2006. Complete sequence data support lack of balancing selection on PRNP in a natural Chinese population. J.Hum.Genet. 51:451-454

             [Full text]       [PDF]

Shuhua Xu*, Dongsheng LU, Li Jin. 2011. Exome Sequencing versus Whole-Genome Genotyping: Lessons from Population Genomics of High-Altitude Adaptations. 12th International Congress of Human Genetics (ICHG) / 61st Annual Meeting of ASHG: Oct 11-15, 2011, Montreal, Canada.

 

Shuhua Xu, Li Jin. 2011. A Genome-Wide Study of Population Structure and Individual Admixture in Kazakhs: Implications for Genetic History and Gene Mapping. HUGO Human Genome Meeting 2011: March 14-17, 2011, Dubai, UAE.

 

Shuhua Xu, Shilin Li, Yajun, Yang, Wenfei Jin, Haiyi Lou, Jiucun Wang, Hongyan Wang, Yiping Shen, Bailin Wu, Li Jin. 2010. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. The 60th Annual Meeting of ASHG: November 2-6, 2010, Washington DC, USA.

 

Shuhua Xu, Li Jin. 2010. Chromosome-Wide Haplotype Sharing: Integrating Recombination Information into Studies on Human Population Genetic Relationship. HUGO Human Genome Meeting 2010: May 18-21, 2010, Montpellier, France.

 

Shuhua Xu, Shilin Li, Wenfei Jin, Haiyi Lou, Ling Yang, Xiaohong Gong, Xuejun Zhang, Xianyong Yin, Yungang He, Yajun Yang , Yi Wang, Wenqing Fu, Yu An, Jingze Tan, Jiucun Wang, Ji Qian, Xin Zhang, Yangfei Sun, Hongyan Wang ,Bailin Wu , Li Jin. 2009. Analysis of Genetic Substructure of Han Chinese Using Genome-Wide SNP Arrays: Implication for Association Studies. The 59th Annual Meeting of ASHG: October 20-24, 2009, Honolulu, Hawaii.

 

Shuhua Xu, Li Jin. 2008. Inferring Human Population Structure: STR or SNP?. The 58th Annual Meeting of ASHG: November 11-15, 2008, Philadelphia, Pennsylvania.

 

Shuhua Xu, Li Jin. 2007. Transferability of HapMap tagSNPs in 70 Asian Populations. The 57th Annual Meeting of ASHG: October 23-27, 2007, San Diego, California.

 

Shuhua Xu, Wei Huang, Ying Wang, Haifeng Wang, Ji Qian, and Li Jin. 2006. Comparison of two admixed populations for MALD: 2,000 years versus 200 years. The 56th Annual Meeting of ASHG:292-1562A; October 1569-1513,

Meeting Abstracts