Main directions:

  • Molecular mechanisms of development and aging in humans and non-human primates

  • Comparative biology of the human brain

  • General study of regulatory evolution with a focus on humans and closely related primate species

Molecular Lifespan Project

The main goal of this project is to characterize general features of regulatory and structural changes associated with age and to identify the key changes specific to the human development and aging. In order to achieve this goal, we are measuring gene expression including miRNA, mRNA and ncRNA, protein expression as well as metabolites and lipids abundance in humans, chimpanzees, and rhesus macaques throughout the entire lifespan of these species.


Comparative Biology of the Human Brain

In this project, we attempt gaining a broad view of the human brain molecular biology by measuring miRNA, mRNA and ncRNA expression, protein composition and metabolic and lipid composition in the distinct brain regions and in the specific cellular fractions. Further, we compare these results with the changes that took place during human evolution, as well as changes observed in human disorders affecting brain functionality.


Principles of Regulatory Evolution

Here, we are trying to discern general rules of regulatory evolution in primates by putting together miRNA, mRNA, ncRNA, and protein expression differences observed between closely related primate species and the DNA sequence data of conservation, divergence and polymorphism patterns observed in humans and other species.
  PICB Jing Dong Han
Yixue Li
CAS-MPG Partner Institute for Computational Biology
Shanghai Institute for Biological Sciences
Chinese Academy of Sciences
  MPI for Evolutionary Anthropology Svante Pääbo
Janet Kelso
Barbara Treutlein
Department of Evolutionary Genetics
Max Planck Institute for Evolutionary Anthropology
  LMU University Clinic Dan Rujescu
Clinic of Psychiatry
LMU University Clinic
  MPI for Molecular Plant Physiology Lothar Willmitzer
Department of Molecular Physiology
Max Planck Institute of Molecular Plant Physiology
  University of Cambridge Sabine Bahn
Institute of Biotechnology
University of Cambridge
  MPI for Molecular Genetics Martin Vingron
Department of Computational Molecular Biology
Max Planck Institute for Molecular Genetics
  Max Delbrück Center for Molecular Medicine Wei Chen
The Berlin Institute for Medical Systems Biology
Max Delbrück Center for Molecular Medicine
  Shanghai Institute for Biological Sciences Rong Zeng
Jiarui Wu
Key Lab for Systems Biology
Shanghai Institute for Biological Sciences
Chinese Academy of Sciences
  MRC Human Genetics Unit Martin Taylor
Evolutionary Genetics and Genomics
The Medical Research Council Human Genetics Unit
  Institute for Information Transmission Problems Mikhail S. Gelfand
Institute for Information Transmission Problems
Russian Academy of Sciences
2016 Comparative Biology Group