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Genome biology and engineering (Yang Lab)

Shanghai Institute of Nutrition and Health, CAS

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News

  • 2021 February: Congratulations to Xu-Kai, Wei and Li for their contribution to a method paper published in Methods. Well done!

  • 2021 February: Fang and Li has contributed an article in Methods. Congratulations to Fang and Li!

  • 2021 January: Congratulations to Wei, Xu-Kai and Li for their contribution to a review article published in Sci. China Life Sci. Well done!

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Research

The completion of the human genome project (HGP) in the beginning of this century and the application of affordable high-throughput sequencing technologies in the past decade have led life science researches to the post-genome era. The resulting wealth of deep-sequencing datasets at genome (including epi-genome) and transcriptome (including epi-transcriptome) levels challenges us to fully understand how functional genomic elements are transcribed and regulated, thus leading to human health and/or diseases. Importantly, the advent of novel genome editing technologies provides us powerful methods to change genetic information at desired target sites at single nucleotide resolution, which benefits not only basic research aiming to decipher how different genotypes result in distinct phenotypes but also pre-clinical study potential to cure human diseases caused by genetic mutations. Since established in 2011, my lab has continuously developed and applied novel computational strategies, together with the-state-of-the-art deep-sequencing technologies and diverse biochemical methods, to dissect complex expression, novel function and potential application of long noncoding RNAs (lncRNAs), especially structured ones such as covalently-closed circular RNAs (circRNAs) from back-splicing. In addition, a new research interest in my lab has been focusing on the invention of novel base editing technologies, along with distinct mechanisms of their unintended off-target effects for further improvement. These research findings shed new light on the functional potential of previously-underappreciated circRNAs, and provide powerful genome editing systems to achieve precise genetic changes in the application of biomedical research, biotechnology and therapeutics.

Research Achievements

1. Genome-wide profiling and characterization of functional circRNAs

2. Nucleotide editing modification and genome base editing technologies

Contact

Address: 320 Yue Yang Road, Shanghai 200031, P.R.China

Telephone: (+86)-21-54920233

Email: liyang@@picb.ac.cn


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