Welcome to Wei Lab!
One of the big challenges in precision medicine is to determine the contribution of sequence variants in the genome to hereditary phenotypes and diseases. Our research focuses on understanding the mechanism of the complex traits and disease, by investigating the molecular processes that link genotype to phenotype, identifying the underlying genes, and quantifying their contributions. We are interested in investigating variation at the level of the genome, transcriptome, alternative splicing, and post-transcription regulation, which were integrated into higher-level phenotypes. Our long-term goal is to dissect the mechanism of how phenotypic heterogeneity is generated, linking individual polymorphisms to changes in gene expression and regulation, which in turn lead to physiological changes and ultimately to human health and disease risk.