Since 2015

  1. Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen L, Wang Y, Wong CL , Xiao XG, Wang Z, Extensive translation of circular RNAs driven by N6-methyladenosine, Cell research. 2017; in press
  2. Wang F, Fu X, Chen P, Wu P, Fan X, Li N, Zhu H, Jia TT, Ji H, Wang Z, Wong CC, Hu R, Hui J. SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. Cell research. 2017; PMID: 28084329
  3. Hu J, Khodadadi-Jamayran A, Mao M, Shah K, Yang Z, Nasim MT, Wang Z, Jiang H. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nature communications. 2016; 7:13347. PMID: 27824034, PMCID: PMC5105168
  4. Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL. Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS genetics. 2016; 12(9):e1006282. PMID: 27618312, PMCID: PMC5019403
  5. Dominguez D, Tsai YH, Gomez N, Jha DK, Davis I, Wang Z. A high-resolution transcriptome map of cell cycle reveals novel connections between periodic genes and cancer. Cell research. 2016; 26(8):946-62. PMID: 27364684, PMCID: PMC4973334
  6. Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, Li H, Zhao X, Keles S, Wang Z, Chang Q. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS genetics. 2016; 12(6):e1006129. PMID: 27352031, PMCID: PMC4924826
  7. Qi Y, Yu J, Han W, Fan X, Qian H, Wei H, Tsai YH, Zhao J, Zhang W, Liu Q, Meng S, Wang Y, Wang Z. A splicing isoform of TEAD4 attenuates the Hippo-YAP signaling to inhibit tumour proliferation. Nature communications. 2016; 7:ncomms11840. PMID: 27291620, PMCID: PMC4909989
  8. Dominguez D, Tsai YH, Weatheritt R, Wang Y, Blencowe BJ, Wang Z. An extensive program of periodic alternative splicing linked to cell cycle progression. eLife. 2016; 5. PMID: 27015110, PMCID: PMC4884079
  9. Du P, Miao C, Lou Q, Wang Z, Lou C (co-corresponding author). Engineering Translational Activators with CRISPR-Cas System. ACS synthetic biology. 2016; 5(1):74-80. PMID: 26414660
  10. Wang Y, Wang Z. Design of RNA-Binding Proteins: Manipulate Alternative Splicing in Human Cells with Artificial Splicing Factors. Methods in molecular biology (Clifton, N.J.). 2016; 1421:227-41. PMID: 26965269
  11. Wei H, Wang Z. Engineering RNA-binding proteins with diverse activities. Wiley interdisciplinary reviews. RNA. 2015; 6(6):597-613. PMID: 26329122
  12. Szempruch AJ, Choudhury R, Wang Z, Hajduk SL. In vivo analysis of trypanosome mitochondrial RNA function by artificial site-specific RNA endonuclease-mediated knockdown. RNA. 2015; 21(10):1781-9. PMID: 26264591, PMCID: PMC4574754
  13. Wang Z. Not just a sponge: new functions of circular RNAs discovered. Science China: Life sciences. 2015; 58(4):407-8. PMID: 25680857
  14. Tsai YS, Dominguez D, Gomez SM, Wang Z. Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors. Oncotarget. 2015; 6(9):6825-39. PMID: 25749525, PMCID: PMC4466652
  15. Wang Y, Wang Z. Efficient backsplicing produces translatable circular mRNAs. RNA. 2015; 21(2):172-9. PMID: 25449546, PMCID: PMC4338345

  16. 2004 - 2015

  17. Wang Y, Chen D, Qian H, Tsai YS, Shao S, Dominguez D and Wang Z. RBM4 specifically controls alternative splicing to suppress tumor progression (2014) Cancer Cell 26(3):374-389. doi: 10.1016/j.ccr.2014.07.010.*Highlighted by Research Watch article “RBM4-regulated alternative splicing suppresses tumorigenesis” Cancer Discovery 2014 Nov;4(11):1253. doi: 10.1158.
  18. TsaiY, Gomez SM, and Wang Z. Prevalent RNA recognition motif duplication in the human genome. RNA (2014) May;20(5):702-12. doi: 10.1261/rna.044081.113
  19. Choudhury R, Ghose Roy S, Tsai YS, Tripathy A , Graves LM and Wang Z. The splicing activator DAZAP1 integrates splicing control into MEK/Erk regulated cell proliferation and migration.  Nature Communications (2014) Jan 23;5:3078. doi: 10.1038/ncomms4078
  20. Matera AG and Wang Z. Ribonucleoprotein assembly and dynamics: A day in the life of the spliceosome. Nature Review Mol Cell Biol. (2014) Jan 23;15(2):108-21. doi: 10.1038/nrm3742
  21. Wang Y and Wang Z. Systematical identification of splicing regulatory cis-elements and cognate trans-factors Methods (2013). Aug 22. doi:pii: S1046-2023(13)00326-5
  22. Zhang W, Wang Y, Dong S, Choudhury R, Jin Y, and Wang Z. Treatment of type 1 Myotonic Dystrophy by engineering site-specific RNA endonucleases that target (CUG)n repeats. Molecular Therapy. (2013) Oct 23. doi: 10.1038/mt.2013.251. [Epub ahead of print]
  23. Wang Y, Wang Z* and Hall TM* ( *co-corresponding author). Engineered proteins with PUF scaffold to manipulate RNA metabolism. FEBS J. (2013) Jun 3. doi: 10.1111/febs.12367 invited review
  24. Wang Y, XiaoX, ZhangJ, ChoudhuryR, Robertson A, Li K, Ma M, BurgeCB and Wang Z.  A complex network of factors with overlapping affinities control splicing repression by intronic elements.  Nature Structure Molecular Biology  2012 Dec 16. doi: 10.1038/nsmb.2459. [Epub ahead of print]
  25. Choudhury R, Dominguez D, Wang Y and Wang Z. Engineering RNA endonucleases with customized sequence specificities (2012). Nature Communication 2012;3:1147. doi: 10.1038/ncomms2154.
  26. Wang Y, Ma M, Xiao XS and Wang Z. Intronic splicing enhancers, cognate splicing factors and context dependent regulation rules.  (2012) Nature Structure Molecular Biology  2012 Oct;19(10):1044-52. doi: 10.1038/nsmb.2377. Epub 2012 Sep 16.
  27. Zhu H, Urban DJ, Blashka J, McPheeters MT, Kroeze WK, Mieczkowski P, Overholser JC, Jurjus GJ, Dieter L, Mahajan GJ, Rajkowska G, Wang Z, Sullivan PF, Stockmeier CA, Roth BL. Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders. (2012) PLoS One, 7(8):e43227. Epub 2012 Aug 17.
  28. Dong S, Wang  Y, Cassidy-Amstutz C, Lu G, Bigler R, Li C, Jezyk MR, Hall TM, Wang Z. A specific and modular binding code for cytosine recognition in PUF domains. (2011) J Biol Chem. 2011 Jul 29;286(30):26732-42. Epub 2011 Jun 8.   *Selected as the paper of the week by J Bio. Chem.*Recommended by an editorial comment in Chem Biol. 2011 Jul 29;18 (7):821-3.
  29. Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL. Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. (2010) Nucleic Acids Res. 38(10):e118. Epub 2010 Feb 25.
  30. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. (2010) PloS Genet, 6(12):e1001233.
  31. Wang Y, Cheong CG, Hall TM, Wang Z. Engineering splicing factors with designed specificities (2009) Nature Methods 6(11):825-30. Epub 2009 Oct 4. * Recommended by Faculty of 1000 * Commented by Science-Business eXchange
  32. Xiao X, Wang Z, Jang M, Nutiu R, Wang ET, Burge CB. Splice site strength-dependent activity and genetic buffering by poly-G runs. Nature Struct Mol Biol, 2009, 16(10):1094-100. Epub 2009 Sep 13.
  33. Wang Z* (* corresponding author), Burge CB. Splicing regulation: From a parts list of regulatory elements to an integrated splicing code.  (2008) RNA (in press, Review).
  34. Xiao X, Wang Z, Jang M, Burge CB.  Coevolutionay networks of splicing cis-regulatory elements. (2007) PNAS 104: 18583-18588
  35. Wang Z, Xiao X, Van Nostrand E and Burge CB. General and specific functions of exonic splicing silencers in splicing control (2006) Molecular Cell 23(1):61-70. Epub 2006 Jun 22. (cover article).
  36. Wang Z, Rolish M, Yeo G, Tung V, Mawson M and Burge CB.  Systematic identification and analysis of exonic splicing silencers  (2004) Cell 119 (6): 831-845.  *Rated exceptional by Faculty of 1000 

  37. Before 2003

  38. Drew ME*, Morris JC*, Wang Z* (* co-first author), Wells L, Sanchez M, Landfear SM, and Englund PT.  The adenosine analog tubercidin inhibits glycolysis in trypanosoma brucei as revealed by an RNAi library (2003) J. Biol Chem.  278(47): 46596-46600.
  39. Wang Z, Drew ME, Morris JC, and Englund PT.  Asymmetrical division of trypanosome’s kinetoplast DNA network. (2002) EMBO J. 21(18): 4998-5005.
  40. Morris JC*, Wang Z*, Drew ME* (* co-first author), and Englund PT.  Glycolysis modulates Trypanosome glycoprotein expression as revealed by an RNAi library. (2002) EMBO J. 21(17):4429-4438.
  41. Grahms J, Morris JC, Drew ME, Wang Z, Englund PT, Hajduk SL. A trypanosome mitochondrial RNA polymerase is required for transcription and replication. (2002) J. Biol. Chem.  277 (19): 16952-9.
  42. Wang Z and Englund PT. RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA (2001) EMBO J.  20(17): 4674-83
  43. Morris JC*, Wang Z*, Drew ME*, Paul KS* (* co-first author), and Englund PT. Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector.  (2001) Mol Biochem Parasitol. 117(1):111-3.
  44. Klingbeil MM, Drew ME, Liu Y, Morris JC, Motyka SA, Saxowsky TT, Wang Z, and Englund PT.  Unlocking the secret of Trypanosome kinetoplast DNA network replication. (2001)Protist 152: 255-262.  Review.
  45. Morris JC, Drew ME, Klingbeil MM, Motyka SA, Saxowsky TT, Wang Z, and Englund PT. Replication of kinetoplast DNA: an update for the new millennium. (2001) Int J Parasitol. 31(5-6):453-8.  Review.
  46. Wang Z*, Morris JC*, Drew ME* (* co-first author), and Englund PT.  Inhibition ofTrypanosoma brucei gene expression by RNA Interference:  A survey using an integratable vector with opposing T7 Promoters.  (2000) J Biol Chem.  275: 40174-40179.
  47. Mair G, Shi H, Li H, Djikeng A, Aviles HO, Bishop JR, Falcone FH, Gavrilescu C, Montgomery JL, Santori MI, Stern LS, Wang Z, Ullu E, Tschudi C.  A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA. (2000) RNA. 6(2):163-9.
  48. Wang HR, Wang Z, Zhang T, and Zhou HM.  Kinetics of irreversible inhibition of aminoacylase by MNP. (1996) Progress in Natural Science 6: 84-90.
  49. Wang HR, Zhang T, Wang Z, Wang XC, and Zhou HM. Aminoacylase from pig kidney contains no disulfide bonds. (1995) Scince in China (Series B) 38(12): 1448-1454.
  50. Wang Z, Yang Y, Zhou HM. Conformational changes of active sites during refolding of urea-denatured creatine kinase. (1995) Biochimie 77:953-956.
  51. Wang Z, Huang MQ, Zou XM, Zhou HM. Unfolding, conformational change of active sites and inactivation of creatine kinase in SDS solutions. (1995) Biochim. Biophys. Acta.  1251: 109-114.
  52. Tang ZY, Yu JY, Zhou Q, He B, Wang Z, Zhou HM. Secondary structure of Holo- and Apo- aminoacylase from prediction, circular dichroism, and FT-Raman spectroscopy.(1995) J. Biochem. 118:706-709.
  53. Wang Z, Xu YK, Zhou HM: Kinetics of irreversible inhibition of creatine kinase during modification by o-phthaldehyde. (1994) Enzyme Protein. 48:1-9.